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FLASH GENE
Symbol ARNT contributors: mct - updated : 20-03-2015
HGNC name aryl hydrocarbon receptor nuclear translocator
HGNC id 700
Location 1q21.2      Physical location : 150.782.185 - 150.849.186
Synonym name
  • hypoxia-inducible factor 1, beta subunit
  • class E basic helix-loop-helix protein 2
  • Synonym symbol(s) DIRT, HIF1B, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2
    DNA
    TYPE functioning gene
    STRUCTURE 67.06 kb     22 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    text structure several transcription start sites
    MAPPING cloned Y linked Y status confirmed
    Map cen - TSHB TSHB - D1S13 ,ARNT ,D1Z5 ,MUC1 - SPTA1 - CRP - APOA2 APOA2 - D1S104 - qter
    Authors Johnson (93)
    Physical map
    ANP32E 1q21.1 acidic (leucine-rich) nuclear phosphoprotein 32 family, member E CA14 1q21 carbonic anhydrase XIV APH-1A 1p36.13-q31.3 likely ortholog of C. elegans anterior pharynx defective 1A FLJ23221 1q21.3 hypothetical protein FLJ23221 LOC148523 1q21.3 hypothetical protein BC017397 MRPS21 1q21 mitochondrial ribosomal protein S21 PRPF3 KIAA0460 1q21.3 KIAA0460 protein FLJ12528 1q21.3 threonyl-tRNA synthetase ECM1 1q21.1-q21.2 extracellular matrix protein 1 TSRC1 1q21.3 thrombospondin repeat containing 1 FLJ13544 1q21.3 hypothetical protein FLJ13544 MCL1 1q21 myeloid cell leukemia sequence 1 (BCL2-related) ENSA 1q21.2 endosulfine alpha GPP34R 1q21.3 GPP34-related protein DKFZP434A1315 1q21.3 hypothetical protein DKFZp434A1315 CTSS 1q21 cathepsin S CTSK 1q21 cathepsin K (pycnodysostosis) ARNT 1q21 aryl hydrocarbon receptor nuclear translocator HCP1 1q21.3 cytochrome c, somatic pseudogene SETDB1 1q21 SET domain, bifurcated 1 LASS2 1q11 LAG1 longevity assurance homolog 2 (S. cerevisiae) ANXA9 1q21 annexin A9 FLJ11280 1q21.3 hypothetical protein FLJ11280 BNIPL 1q21.2 BCL2/adenovirus E1B 19kD interacting protein like HTCD37 1q21 TcD37 homolog FLJ20519 1q21.3 hypothetical protein FLJ20519 SPEC1 1q21.2 hypothetical protein FLJ20519 AF1Q 1q21 hypothetical protein FLJ20519 MGC29891 1q21.3 hypothetical protein MGC29891 SEMA6C 1q21.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C FLJ23467 1q21.3 hypothetical protein FLJ23467 LOC388695 1 similar to hypothetical protein SB145 SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - splicing 2600 - - lowly in liver 2000 11129342
    21 - 4855 - 773 - 2000 11129342
    21 - 4858 - 774 - 2000 11129342
    - - 4903 - 789 - 2000 11129342
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cells
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal basic helix-loop-helix (HLH) motif juxtaposed to a stretch of approximately 300AA, termed the PAS (Per - ARNT - Sim) region, to interact with several transcriptional coactivators that are required for transcriptional initiation after xenobiotic or hypoxic cues
  • a cysteine rich region
  • two PAS (per-arnt-sim) dimerization domains
  • one PAS-associated C-terminal (PAC) domain, to interact with two coiled coil coactivators, TRIP11 and CALCOCO1
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Arnt
    Homologene
    FAMILY PAS superfamily
    CATEGORY transcription factor , receptor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • dioxin receptor translocator, activating genes involved in metabolism, angiogenesis and apoptosis
  • functions as an estrogen receptor beta-selective coactivator
  • functions in concert with RELB in a TNFRSF8-induced negative feedback mechanism
  • basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways as part of dimeric transcriptional regulator complexes with other bHLH-PAS proteins
  • acts as a modulator to bridge the JUN/SP1 interaction and plays a role in EGF-mediated gene expression under normoxic conditions
  • important role for ARNT in anaplerosis, and it may play a critical role in maintaining normal secretion competence of pancreatic beta-cells
  • important regulator of hepatocellular carcinoma growth and metastasis
  • regulates glucose uptake, mitochondrial gene expression, and vascular permeability to control adipose mass and function, providing a target for obesity therapy
  • dioxin-independent co-activator/co-repressor function for ARNT in estrogen signalling
  • redistribution of ARNT from nucleus to cytoplasm involved in suppression of the hypoxia inducible factor-1 function
  • CELLULAR PROCESS cell life, cell death/apoptosis
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with HIF1A and HIF2A
  • obligate heterodimeric partner for bHLH-PAS proteins involved in sensing and coordinating transcriptional responses to xenobiotics, hypoxia, and developmental pathways
  • forms a heterodimer with aryl hydrocarbon receptor or HIF1A to mediate biological responses to xenobiotic exposure and hypoxia
  • INTERACTION
    DNA DNA binding
    RNA
    small molecule
    protein
  • TNFRSF8-interacting protein that modulated the activity of the RELB subunit of the transcription factor nuclear factor kappaB (NF-kappaB)
  • binds to other basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins to form functional transcriptional complexes in order to regulate specific biological pathways
  • MAGED1 binds and positively regulates the transcriptional activity of family members SIM1, SIM2, NPAS4 and ARNT2, but does not interact with AHR, HIF1A and ARNT
  • ARNT plays an important role in the modulation of the dual functions of the AHR
  • cell & other
    REGULATION
    inhibited by cardiovascular basic helix loop helix factor 1,(CHF1) in mouse
    MIR24 (MIR-24-dependent down-regulation of ARNT decreased the expression of its downstream genes such as CYP1A1 and carbonic anhydrase IX)
    repressed by by hydrogen peroxide or reactive oxygen species
    Other NFKB directly regulates ARNT mRNA and protein
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fused with ETV6 in t(1;12)(q21;p13) in acute myeloblastic leukemia
    tumoral fusion      
    with ETV6in t(1;12)(q21;p13), in T-cell lymphoblastic leukemia (T-ALL)
    Susceptibility to oral clefts in Japanese patients
    Variant & Polymorphism SNP
    Candidate gene
  • could be a promising prognostic candidate in hepatocellular carcinoma patients
  • Marker
    Therapy target
    ANIMAL & CELL MODELS