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FLASH GENE
Symbol ARMCX3 contributors: mct/npt - updated : 09-05-2017
HGNC name armadillo repeat containing, X-linked 3
HGNC id 24065
Location Xq22.1      Physical location : 100.878.119 - 100.882.831
Synonym name
  • arm protein lost in epithelial cancers, X chromosome, 3
  • protein ALEX3
  • Synonym symbol(s) MGC12199, ALEX3, KIAA0443, UNQ2517, DKFZp781N1954, dJ545K15.2
    DNA
    TYPE functioning gene
    STRUCTURE 4.71 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text three transcript variants encoding the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 splicing 3395 42 379 - Mou (2009)
    5 splicing 3367 42 379 - Mou (2009)
  • differing in the 5' UTR compared to variant 1
  • 5 splicing 3318 42 379 - Mou (2009)
  • differing in the 5' UTR compared to variant 1
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
     vessel   highly
    Digestiveliver   lowly
    Endocrinethyroid    
    Lymphoid/Immunespleen   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Muscularstriatumskeletal  
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential N-terminal transmembrane domain
  • a single Armadillo (ARM) repeat
  • HOMOLOGY
    interspecies ortholog to murine Armcx3
    Homologene
    FAMILY
  • ALEX family
  • CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    text integral membrane protein of the mitochondrial outer membrane (Mou 2009)
    basic FUNCTION
  • may play a role in tumor suppression
  • playing a role in the biological function of an important developmental regulatory factor, SOX10 (Mou 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SOX10-interacting protein increasing the level of mitochondrially associated SOX10 (Mou 2009)
  • ARMCX3 expression levels regulate mitochondrial dynamics and trafficking in neurons, and interacts with the Kinesin/ROTH1,ROTH2/TRAK2 complex in a Ca(2+)-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS