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FLASH GENE
Symbol ARMCX1 contributors: - updated : 23-09-2005
HGNC name armadillo repeat containing, X-linked 1
HGNC id 18073
Location Xq21.33-q22.2      Physical location : 100.805.513 - 100.809.673
Synonym name ARM protein lost in epithelial cancer,X chromosome 1
Synonym symbol(s) ALEX1, DKFZp686P06199
DNA
TYPE functioning gene
STRUCTURE 4.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines derived from sarcomas, neuroblastomas and gliomas
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a potential N-terminal transmembrane domain
  • two Armadillo (ARM) repeats
  • ATP-GTP binding site
  • multiple phosphorylation sites
  • HOMOLOGY
    interspecies ortholog to murine Armcx1
    Homologene
    FAMILY ALEX family
    CATEGORY tumor suppressor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • playing a role in tumor suppression, possibly by being involved in the regulation of normal cell growth
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   LOH    
    lung prostate colon pancreas and ovarian carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS