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FLASH GENE

Symbol

ARMC4

contributors: mct - updated : 05-10-2013

HGNC name	armadillo repeat containing 4
HGNC id	25583

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ICS24 immotile cilia syndrome 24
Location	10p12.1      Physical location : 28.101.098 - 28.287.977
Synonym symbol(s)	FLJ10376, FLJ10817, FLJ32798, DKFZP434P1735, RP11-691I13.1

DNA

TYPE	functioning gene
STRUCTURE	186.88 kb     20 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018076 20 - 3572 NP_060546 115.5 1044 - 2013 2384977

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis       Respiratory lung         Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Respiratory ciliari cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	10 Armadillo repeat motifs (ARMs)
	one HEAT repeat

HOMOLOGY

interspecies	homolog to drosophila gudu
	homolog to murine Armc4

Homologene

FAMILY	beta-catenin family
	ARM super-family

CATEGORY

unknown/unspecified

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytoskeleton,intermed filament
text	expressed in multiciliated airway cells

basic FUNCTION	axonemal protein that is necessary for proper targeting and anchoring of outer dynein arms
	functional role in the establishment of left-right asymmetry
	ciliary protein required for correct axonemal docking and targeting of outer dynein arm components and/or complexes
	Gudu and ARMC4 are a subfamily of Armadillo-repeat containing proteins that may have an evolutionarily conserved function in spermatogenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

TTC25 is essential for the assembly of all three known ODA- docking complex proteins, CCDC151, CCDC114, or ARMC4

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ICS24

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS