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FLASH GENE
Symbol ARMC2 contributors: mct - updated : 19-03-2019
HGNC name armadillo repeat containing 2
HGNC id 23045
Corresponding disease
MMAFS2 multiple morphological abnormalities of the flagella syndrome 2
Location 6q21      Physical location : 109.169.618 - 109.295.350
Synonym name hypothetical protein LOC84071
Synonym symbol(s) bA787I22.1, DKFZP434P0714, RP11-787I22.1, FLJ18267, FLJ99854
DNA
TYPE functioning gene
STRUCTURE 140.68 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
Physical map
SEC63 6q21 SEC63-like (S. cerevisiae) LOC285752 6q21 similar to ribosomal protein L3; 60S ribosomal protein L3; HIV-1 TAR RNA-binding protein B OSTM1 6q21 osteopetrosis associated transmembrane protein 1 NR2E1 6q21 nuclear receptor subfamily 2, group E, member 1 SNX3 6q13-q22.3 sorting nexin 3 LACE1 6q22.1 lactation elevated 1 FOXO3A 6q21 forkhead box O3A LOC391958 6 similar to zinc finger protein 259; zinc finger protein ZPR1 ARMC2 6q21 armadillo repeat containing 2 SESN1 6q21 sestrin 1 C6orf182 6q21 chromosome 6 open reading frame 182 LOC389422 6 LOC389422 FLJ37396 6q21 hypothetical protein FLJ37396 C6orf184 6q21 chromosome 6 open reading frame 184 LOC345875 6q21 similar to ribosomal protein L7-like 1 C6orf185 6q21 chromosome 6 open reading frame 185 CD164 6q21 CD164 antigen, sialomucin PPIL6 6q21 peptidylprolyl isomerase (cyclophilin)-like 6 SMPD2 6q22.1 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) NICAL 6q21 NEDD9 interacting protein with calponin homology and LIM domains ZNF450 6q22.1 zinc finger protein 450 FLJ25791 6q21 hypothetical protein FLJ25791 LOC389423 6 LOC389423 C6orf199 6q21 chromosome 6 open reading frame 199 KIAA0274 6q21 KIAA0274
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3736 96.7 867 - 2008 18978678
17 - 3663 - 702 - 2008 18978678
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  predominantly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 42-amino-acid motif composed of three alpha helices
  • HOMOLOGY
    interspecies ortholog to murine LOC213402
    Homologene
    FAMILY
  • ARM super-family, ARM-repeat-containing protein family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • is necessary for sperm flagellum structure and assembly, for spermatogenesis and, in particular, for sperm flagellum structure and motility
  • might be specifically involved in the central-pair complex (CPC) of microtubules assembly or stability
  • is essential for sperm-tail biogenesis and mutations in this gene lead to drastic flagellum malformations
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMAFS2
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS