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FLASH GENE

Symbol

ARL5A

contributors: - updated : 20-02-2006

HGNC name	ADP-ribosylation factor-like 5A
HGNC id	696

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	2q23.3      Physical location : 152.657.479 - 152.685.009
Synonym name	ADP-ribosylation factor-like 5
Synonym symbol(s)	ARL5, ARFLP5

DNA

TYPE	functioning gene
STRUCTURE	27.00 kb     6 Exon(s)

regulatory sequence

Locus Control Region

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 - splicing 3169 20.7 179 - Lin, Wang variant 2 - splicing 2911 - 142 - Lin, Wang lacks an alternate segment in the 5' UTR variant 3 - splicing 2913 - 142 - Wang lacks alternate segments in the 5' UTR

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       moderately Endocrine pancreas       moderately Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Muscular striatum skeletal

cell lineage
cell lines	liver carcinoma cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	six GTP binding motifs
	four conserved motifs critical for guanine nucleotide binding and hydrolysis
	a C-terminal consensus ARF motif

conjugated

LipoP

mono polymer

monomer

HOMOLOGY

interspecies	homolog to Drosophila CG7197
	ortholog to C.elegans Arl5
	homolog to C.elegans B0336.2

Homologene

FAMILY	small GTPase superfamily
	ADP-ribosylation factors (ARF) family

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleolus

basic FUNCTION	having a GTPase activity
	may playing a role(s) in nuclear dynamics and/or signaling cascades during embryonic development

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule	nucleotide,
	GTP

protein

binding heterochromatin protein 1 alpha

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS