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FLASH GENE
Symbol ARL4D contributors: mct - updated : 03-02-2010
HGNC name ADP-ribosylation factor-like 4D
HGNC id 656
Location 17q21.31      Physical location : 41.476.352 - 41.478.503
Synonym name
  • ADP-ribosylation factor-like 6
  • ADP-ribosylation factor 4-like
  • Synonym symbol(s) ADPRF, ARF4L
    DNA
    TYPE functioning gene
    STRUCTURE 2.15 kb     2 Exon(s)
    MAPPING cloned Y linked N status confirmed
    Map see BRCA1 BRCA1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1602 - 201 - 2007 17398095
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Reproductivefemale systemuteruscervix  
    Visualeye   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine Arfl4
    ortholog to rattus Arf4l_predicted
    Homologene
    FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • ARL4 family
  • CATEGORY enzyme , motor/contractile
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text
  • localization at the plasma membrane is GTP- and N-terminal myristoylation-dependent (17804820)
  • basic FUNCTION
  • involved in vesicular transport
  • driving the transport of cargo protein and subsequent fusion of recycling vesicles with the plasma membrane for maintenance of the cell surface
  • acting as a novel upstream regulator of cytohesin-2 (CYTH2) to promote ARF6 activation and modulate actin remodeling
  • with ARL4C, and ARL4A, are able to recruit CYTH2 and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form
  • regulator of neurite formation through cytohesin-2 and ARF6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    Arl4 family thus defines a signal-transduction pathway that can mediate the plasma-membrane recruitment of cytohesins independently of a requirement for the generation of PtdIns(3,4,5)P(3)
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • low molecular weight GTP binding
  • interacts with the C-terminal pleckstrin homology (PH) and polybasic c domains of cytohesin-2(CYTH2) in a GTP-dependent manner
  • cell & other
    REGULATION
    Other its expression is controlled by the activated Akt/mTOR pathway, which is a downstream effect of the loss of PTEN function (Chi 2008)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS