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FLASH GENE
Symbol ARL4C contributors: mct/npt - updated : 03-02-2010
HGNC name ADP-ribosylation factor-like 4C
HGNC id 698
Location 2q37.1      Physical location : 235.401.687 - 235.405.693
Synonym name
  • ADP-ribosylation factor-like 7
  • ADP-ribosylation factor-like protein LAK
  • Synonym symbol(s) LAK, ARL7
    DNA
    TYPE functioning gene
    STRUCTURE 4.01 kb     1 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 4024 - 192 - Wei (2009)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   moderately
     thymus   highly
    Cardiovascularheart   highly
    Endocrinepancreas   highly
    Nervousbrain   moderately
    Reproductivemale systemprostate  moderately
    Respiratorylung   moderately
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to Drosophila CG2219
    homolog to C.elegans B0336.2
    Homologene
    FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • having a GTPase activity
  • exchanging GDP and GTP
  • may be involved in a vesicular transport step between a perinuclear compartment and the plasma membrane (Engel 2004)
  • with ARL4A, and ARL4D, are able to recruit CYTH2 and other cytohesins to the plasma membrane by binding to their PH domains irrespective of whether they are in the diglycine or triglycine form (Hofmann 2007)
  • involved in the AI-dependent cholesterol secretion process (Wei 2009)
  • might modulate the intracellular vesicular transport via interaction with microtubules (Wei 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • GDP
  • protein
  • interacts with alpha-tubulin and modulates intracellular vesicular transport (Wei 2009)
  • cell & other
    REGULATION
    induced by cholesterol loading and participates in apolipoprotein AI-dependent cholesterol export (Engel 2004)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS