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FLASH GENE
Symbol ARL15 contributors: mct/npt - updated : 06-02-2024
HGNC name ADP-ribosylation factor-like 15
HGNC id 25945
Location 5q11.2      Physical location : 53.180.613 - 53.606.403
Synonym name
  • ADP-ribosylation factor related protein 2
  • ARF-related protein 2
  • Synonym symbol(s) ARFRP2, FLJ20051
    DNA
    TYPE functioning gene
    STRUCTURE 425.80 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 2501 22.7 204 - 2022 36302536
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunespleen   moderately
     thymus   highly
    Urinarybladder   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal predominantly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • RAS superfamily of small GTPases
  • ADP-ribosylation factors (ARF) family
  • transmembrane Bax inhibitor 1 (BI1) motif family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text . ARL15 localized to the cytoplasm in the resting state and accumulated in the Golgi apparatus around the nucleus upon insulin stimulation
    basic FUNCTION
  • may be an upstream mediator of the relationship between insulin and adiponectin (Richards 2009)
  • ARL15 plays a role in adipocyte differentiation and adiponectin secretion
  • palmitoylation dependent trafficking-related role of ARL15 as a regulator of adipocyte differentiation via ARL6IP5 interaction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • GTP
  • protein
  • ASAP2 is an ARL15-interacting protein
  • ARL15 is required for forming complex N-glycosylation of CNNMs
  • overexpression of ARL15 promotes complex N-glycosylation of CNNM3
  • ARL15 is a novel negative regulator of Mg2+ transport by promoting the complex N-glycosylation of CNNMs
  • potential interacting partner of ARL15, is the ER-localised protein ARL6IP5
  • ARL15 has been identified as CNNM-binding partner and an inhibitor of divalent cation influx by TRPM7
  • ARL15 also inhibits CNNM2 Mg2+ efflux
  • cell & other
    REGULATION
    activated by by insulin stimulation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to coronary heart disease (CHD)
  • to lipodystrophy
  • Variant & Polymorphism other
  • rs4311394-G, associated with a higher risk of CHD (Richards 2009)
  • haploinsufficiency predisposes likely to lipodystrophy
  • Candidate gene good candidate to be involved in cellular insulin resistance and/or adiponectin trafficking and secretion (Richards 2009)
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunearticular
    is a viable target for the treatment of rheumatoid arthritis
    ANIMAL & CELL MODELS