basic FUNCTION
| required for ciliogenesis, body axis formation, and renal function |
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being capable of self-associating via N domain, and overexpression of N domain inhibits not only cilia formation but also the maintenance of pre-generated cilia |
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conserved role for the SUMOylation modification of ciliary small GTPase ARL13B in specifically regulating the proper ciliary targeting of various sensory receptors |
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SUMOylated ARL13B is the key determinant in regulating the specific ciliary targeting of various sensory receptors |
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role for ARL13B in endocytic recycling traffic, suggesting a link between ARL13B function and the actin cytoskeleton |
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increases cilia length by inducing protrusion of the ciliary membrane, which is then followed by the extension of the axonemal microtubules |
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is an important effector of ciliary membrane biogenesis and ciliary length regulation |
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regulates cell migration and cell cycle progression |
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ARL13B regulates IFT-A-mediated retrograde protein trafficking within cilia through its interaction with INPP5E |
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is a membrane-associated G-protein that localizes along the cilium and functions in protein transport and signaling |
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function of ARL13B in anchoring ciliary membrane proteins to the axoneme through the direct interaction of its G-domain with tubulin |
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controls axoneme polyglutamylation, which is marginally required for cilia stability but essential for cilia signaling |