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FLASH GENE
Symbol ARL1 contributors: mct - updated : 27-10-2015
HGNC name ADP-ribosylation factor-like 1
HGNC id 692
Location 12q23.3      Physical location : 101.786.922 - 101.801.572
Synonym symbol(s) ARFL1
DNA
TYPE functioning gene
STRUCTURE 14.67 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - D11S346 - D11S332 - D11S1727 - D11S1607 - IGF1 - MYBPC1 - ARL1 - D11S560 - D11S78 - qter
Authors GeneMap (98)
Physical map
MGC39520 12q23.2 hypothetical protein MGC39520 LOC387878 12 similar to ribosomal protein S4, X-linked KIAA0701 12q23.1-q23.3 similar to ribosomal protein S4, X-linked DKFZp434M0331 12q23.3 hypothetical protein DKFZp434M0331 ACTR6 12q23.3 actin-related protein 6 FLJ33505 12q23.3 hypothetical protein FLJ33505 FLJ10074 12q23.3 hypothetical protein FLJ10074 SLC17A8 12q23.3 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 NR1H4 12q21.3 nuclear receptor subfamily 1, group H, member 4 LOC283431 12q23.3 hypothetical protein LOC283431 PIGAP1 12q21 phosphatidylinositol glycan, class A, pseudogene 1 TMEM16D 12q23.3 transmembrane protein 16D (eight membrane-spanning domains) SLC5A8 12q23.3 solute carrier family 5 (iodide transporter), member 8 DRIM 12q23 down-regulated in metastasis ARL1 12q23.3 ADP-ribosylation factor-like 1 SPIC 12q23.3 likely ortholog of mouse Spi-C transcription factor (Spi-1/PU.1 related) MYBPC1 12q22-q23 myosin binding protein C, slow type CHPT1 12q11 choline phosphotransferase 1 SYCP3 12q24.2-q24.3 synaptonemal complex protein 3 MGC4170 12q23.3 synaptonemal complex protein 3 LOC387880 12 similar to 10 KD HEAT SHOCK PROTEIN, MITOCHONDRIAL (HSP10) (10 KD CHAPERONIN) (CPN10) FLJ11259 12q23.3 hypothetical protein FLJ11259 LOC390353 12 similar to ribosomal protein L9 CGI-116 12q23.3 CGI-116 protein Nup37 12q23.3 nucleoporin Nup37 FLJ20641 12q23.3 hypothetical protein FLJ20641 PMCH 12q23.1 pro-melanin-concentrating hormone IGF1 12q23.1 insulin-like growth factor 1 (somatomedin C) PAH 12q23.1 phenylalanine hydroxylase ASCL1 12q23.1 achaete-scute complex-like 1 (Drosophila) FLJ25323 12q23.3 FLJ25323 protein
RNA
TRANSCRIPTS type messenger
text 3.2-,1.7- and 1.2-kb ARL1 mRNAs in all human tissues tested except brain which had only the 3.2-kb species (Hong)
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 3215 - 181 - 2009 19224922
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrinepancreas    
Nervousbrain    
Reproductivemale systemprostate   
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Drosophila Arf72A
homolog to C.elegans arl-1
Homologene
FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • stimulating phospholipase D
  • enhancing cholera toxin catalyzed ADP-ribosyltransferase activity
  • having function to recruit GOLGA1 and GOLGA4 onto the Golgi via interacting with their GRIP domains
  • ARFRP1 and ARL1, which are both ARF-like small GTPases, regulate retrograde transport of Shiga toxin to the TGN
  • mediates localization of two TGN golgins GOLGA1 and GOLGA4
  • determines the trans-Golgi association of arfaptins (ARFIP1, ARFIP2)
  • regulator of post-Golgi vesicle tethering
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP
    protein
  • is necessary for Golgi recruitment of ARFGEF1 and ARFGEF2 but not GBF1
  • acts to direct a trans-Golgi-specific ARF1 GEF, and hence active ARF1, to the trans side of the Golgi
  • MON2 is a negative regulator of the monomeric G protein, ARL1
  • ARL1 links RAB4A-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS