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FLASH GENE
Symbol ARIH2 contributors: mct/npt - updated : 16-06-2016
HGNC name ariadne homolog 2 (Drosophila)
HGNC id 690
Location 3p21.31      Physical location : 48.956.280 - 49.022.969
Synonym name
  • all-trans reinoic acid inducible ring finger
  • Triad1 protein
  • Two RING fingers and DRIL1
  • Synonym symbol(s) ARI2, TRIAD1, FLJ10938, FLJ33921
    DNA
    TYPE functioning gene
    STRUCTURE 66.72 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    SCOTIN 3p21.31 scotin PFKFB4 3p22-p21 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 SRP 3p21.3 stresscopin-related peptide COL7A1 3p21.3 collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) UQCRC1 3p21.2 ubiquinol-cytochrome c reductase core protein I LOC344651 3p21.31 hypothetical LOC344651 SLC26A6 3p21 solute carrier family 26, member 6 CELSR3 3p24.1-p21.2 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) AF3P21 3p21 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila) IHPK2 3p21.31 inositol hexaphosphate kinase 2 PRKAR2A 3p21.3-p21.2 protein kinase, cAMP-dependent, regulatory, type II, alpha SLC25A20 3p21.31 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ARIH2 3p21.2-p21.3 ariadne homolog 2 (Drosophila) PH-4 3p21.31 hypoxia-inducible factor prolyl 4-hydroxylase WDR6 15q21 WD repeat domain 6 FLJ10496 3p21.31 hypothetical protein FLJ10496 DKFZP564J0123 3p21.31 nuclear protein E3-3 IMPDH2 3p21.2 IMP (inosine monophosphate) dehydrogenase 2 FLJ20259 3p21.31 FLJ20259 protein QARS 3p21.3-p21.2 glutaminyl-tRNA synthetase USP19 3p21.3-p14.2 ubiquitin specific protease 19 LAMB2 3p21.3-p21.2 laminin, beta 2 (laminin S) FLJ12800 3p21.31 hypothetical protein FLJ12800 MGC35097 3p21.31 hypothetical protein MGC35097 LOC339834 3p21.31 hypothetical protein LOC339834 FLJ43654 3p21.31 FLJ43654 protein USP4 3p21.31 ubiquitin specific protease 4 (proto-oncogene)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4109 57 493 - 2012 22940738
    17 - 4231 - 493 - 2012 22940738
    14 - 3693 - 351 - 2012 22940738
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbrain   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
  • an acidic N-terminal region
  • two ring fingers flanking a conserved cysteme-rich (C6HC) designated DRIL domain (double ring finger-linked domain), two RING (really interesting new gene) domains differentially binding ubiquitin-conjugating enzymes, UE2L3 and UBE2N
  • two C-terminal coiled-coil domain
  • HOMOLOGY
    interspecies homolog to murine Arih2
    Homologene
    FAMILY Ariadne subfamily ligases
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • playing a role of E3 ubiquitin-protein ligase
  • competes for GFI1 binding with as yet to be identified E3 ubiquitin ligases that do mark GFI1 for proteasomal degradation (Marteijn 2007)
  • controls the proliferation of myeloid cells
  • exhibits dual ubiquitin ligase activity and both of its RING domains are crucial to inhibit myeloid cell proliferation
  • proapoptotic protein that promotes TP53 activation in several cancer cell lines
  • CELLULAR PROCESS cell cycle
    cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • binds the E2 ubiquitin-conjugating enzyme UBE2L1 as well as ubiquitinated proteins and supports the formation of ubiquitin chains that are recognized by the proteasome
  • ARIH2 has E3 ubiquitin ligase activity, and HOXA10-overexpressing myeloid cells exhibited a ARIH2-dependent increase in protein ubiquitination
  • negative regulatory mechanism of ARIH2 via MDM2 E3 ligase ubiquitination
  • in dendritic cells (DCs), ARIH2 caused degradation of the inhibitor NFKBIB in the nucleus, which abrogated its ability to sequester, protect and transcriptionally coactivate the transcription factor subunit RELA in the nucleus
  • ARIH1, ARIH2 bind to and are activated by distinct neddylated Cullin-RING ligase complexes
  • ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation
  • HOXA10 actives transcription of the gene encoding ARIH2 during myeloid differentiation
  • cell & other
    REGULATION
    activated by upregulated by retinoic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS