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FLASH GENE
Symbol ARIH1 contributors: mct - updated : 20-10-2013
HGNC name ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
HGNC id 689
Location 15q24.1      Physical location : 72.766.666 - 72.878.895
Synonym symbol(s) HAR, HHARI, UBCH7BP, ARI, HARI, MOP-6, H7-AP2
DNA
TYPE functioning gene
STRUCTURE 112.23 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC123397 15q22.32 similar to 60S ribosomal protein L29 (Cell surface heparin binding protein HIP) FLJ11196 15q22.32 acheron LOC390601 15 similar to keratin 8, type II cytoskeletal - human THAP10 15q22.32 THAP domain containing 10 FLJ20156 15q22.32 hypothetical protein FLJ20156 LOC283675 15q22.32 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC196993 15q22.32 hypothetical protein LOC196993 LOC390602 15 similar to High mobility group protein 1 (HMG-1) (Amphoterin) (Heparin-binding protein p30) LOC196994 15q22.32 similar to hypothetical protein LOC388132 15 similar to 60S ribosomal protein L17 (L23) FLJ13710 15q22.33 hypothetical protein FLJ13710 NR2E3 15q24 nuclear receptor subfamily 2, group E, member 3 MYO9A 15q22-q23 myosin IXA PRSC2 15q22.32 protease, cysteine, 2 (NEDD8 specific) LOC196996 15q22.33 hypothetical protein LOC196996 PKM2 15q24-q25 pyruvate kinase, muscle LOC56965 15q22.33 hypothetical protein from EUROIMAGE 1977056 BRUNOL6 15q24 bruno-like 6, RNA binding protein (Drosophila) HEXA 15q23-q24 hexosaminidase A (alpha polypeptide) FLJ13315 15q22.33 hypothetical protein FLJ13315 LOC388133 15 hypothetical gene supported by AK026491; NM_000976 LOC338949 15q22.33 similar to RIKEN cDNA 4930425N13 LOC390603 15 similar to prohibitin ARIH1 15q24 ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila) GOLGA6 15q22.33 golgi autoantigen, golgin subfamily a, member 6 LOC123346 15q22.33 hypothetical protein LOC123346 BBS4 15q22.3-q23 Bardet-Biedl syndrome 4 DKFZP434B195 15q22.33 hypothetical protein DKFZp434B195 NEO1 15q22.3-q23 neogenin homolog 1 (chicken) LOC388134 15 LOC388134 HCN4 15q24-q25 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 LOC283677 15q22.33 hypothetical LOC283677 MRPS15P1 15q22 hypothetical LOC283677 SDFR1 15q22 stromal cell derived factor receptor 1 B7H3 15q23-q24 B7 homolog 3 LOC388135 15 similar to RIKEN cDNA 6030419C18 gene MGC34741 15q22.33 hypothetical protein MGC34741 LOXL1 15q22 lysyl oxidase-like 1 STOML1 15q22 stomatin (EPB72)-like 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
- - - 2200 - - weakly expressed except in testis where it was predominant 1999 10521492
- - - 2700 - - - 1999 10521492
14 - 5267 - 557 - 2001 11278816
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Respiratorylung   highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone   
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N-terminal canonical RING1 has been shown to be the principal E2-binding region, although RING2 is also required for ligase activity
  • a highly acidic domain
  • a poly (gly) tract in the N terminus
  • two RING fingers and an IBR domains between RING fingers in the central region, with a RING2 from the RING-IBR-RING motif having a completely distinct topology from classical RINGs
  • HOMOLOGY
    interspecies ortholog to ariadne Drosophila
    homolog to murine Arih1
    Homologene
    FAMILY Ariadne subfamily ligases
    CATEGORY enzyme , unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • playing a role of an E3 ubiquitin-protein ligase
  • ARIH1 and PARK2 functioning via a HECT-like mechanism whereby RING1 harbours the E2-binding site and RING2 harbours the active-site cysteine
  • CELLULAR PROCESS protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • UBE2G2 (E2-UbcH7) through the RING1 finger domain
  • E2-UBCH8
  • interacts and co-localizes with UBE2L3 in mammalian cells, particularly in the perinuclear region
  • ARIH1, ARIH2 bind to and are activated by distinct neddylated Cullin-RING ligase complexes
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS