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FLASH GENE
Symbol ARID3C contributors: mct/pgu - updated : 04-10-2011
HGNC name AT rich interactive domain 3C (BRIGHT- like)
HGNC id 21209
Location 9p13.3      Physical location : 34.621.455 - 34.628.011
Synonym name
  • AT-rich interactive domain-containing protein 3C
  • ARID domain-containing protein 3C
  • Brightlike
  • DNA
    TYPE functioning gene
    STRUCTURE 6.56 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text
  • two alternatively spliced, SUMO-I-modified isoforms that include or exclude (delta6) the REKLES-encoding exon 6 (PMID: 21955986)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1239 - 412 - 2002 11959810
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage expressed preferentially within B lineage lymphocytes
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one ARID domain
  • a REKLES domain found only in the ARID3 subfamily (ARID3A, ARID3B, and ARID3C) consisting of two subdomains: a modestly conserved N-terminal REKLESalpha and a highly conserved (among ARID3 orthologous proteins) C-terminal REKLESbeta, and regulating functional properties of the ARID3 DNA binding domain
  • HOMOLOGY
    Homologene
    FAMILY
  • ARID family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    text
  • undergoing nuclear-cytoplasmic shuttling with a fraction localizing within lipid rafts following BCR stimulation
  • basic FUNCTION
  • may be playing roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification
  • additional functional member of the family of ARID proteins, which should be considered in regulatory circuits, previously ascribed to be mediated by ARID3A
  • CELLULAR PROCESS cell cycle
    nucleotide, chromatin organization
    nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS