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FLASH GENE
Symbol ARHGEF7 contributors: mct/pgu - updated : 10-01-2017
HGNC name Rho guanine nucleotide exchange factor (GEF) 7
HGNC id 15607
Location 13q34      Physical location : 111.767.623 - 111.958.080
Synonym name
  • SH3 domain-containing proline-rich protein
  • PAK-interacting exchange factor beta
  • rho guanine nucleotide exchange factor 7
  • similar to a Mouse SH3 domain-containing proline-rich protein, p85SPR
  • putative protein product of Nbla10314
    • Synonym symbol(s) KIAA0142, PIXB, DKFZp761K1021, Nbla10314, DKFZp686C12170, BETA-PIX, COOL1, P85SPR, P85, P85COOL1, P50BP, PAK3, P50
    DNA
    TYPE functioning gene
    STRUCTURE 191.11 kb     20 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   gene pol
    text structure A/T polymorphism at the 32nd base upstream of the intron/exon junction of exon 7
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 splicing 5069 73.1 646 - 2014 25425573
    also called variant 1/shorter isoform a
    19 splicing 5304 - 782 - 2014 25425573
    also called variant 2/isoform b
    20 - 4956 - 646 - 2014 25425573
    also called variant 5/isoform a
    18 - 5375 - 753 - 2014 25425573
    also called variant 4/isoform
    20 - 5525 - 803 - 2014 25425573
    also called variant 3/isoform c
    19 - 5941 - 803 - 2014 25425573
    19 - 4737 - 646 - 2014 25425573
    20 - 4862 - 721 - 2014 25425573
    - - 4645 - 547 - 2014 25425573
    - - 5126 - 625 - 2014 25425573
    - - 4910 - 625 - 2014 25425573
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestivepharynx   highly
    Lymphoid/Immunelymph node   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal SH3 domain
  • a D homology (DH) domain
  • a pleckstrin homology (PH) domain
  • two putative nuclear localization signals (NLS)
  • two leucine zipper motifs and a proline rich region
  • a C-terminal coiled-coil (CC) domain upstream of the PDZ binding motif allowing multimerization of ARHGEF7, which is important for its physiological functions
    • mono polymer heteromer , complex
    HOMOLOGY
    interspecies homolog to murine Arhgef7
    homolog to Drosophila cg7942
    homolog to C.elegans dbr-1
    Homologene
    FAMILY
  • cytoplasmic proteins family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text
  • localizes to the cytoplasm
    • basic FUNCTION
  • activating the Ras-like family of Rho proteins by exchanging bound GDP for GTP
  • stimulating Rho-dependent signal
  • inducing membrane ruffling
  • required for PAK recruitment to CDC42- and RAC1 driven focal complexes
  • with GIT1 regulate HGF-induced lamellipodia formation and WASF2 transport
  • plays an important role in the regulation of spine dynamics through its high-affinity binding to the SHANK PDZ via its C- terminal motif (DETNL)
  • up-regulates SLC9A3 membrane expression and activity by SHANK2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells
  • ARHGEF7-mediated actin polymerization at synapses regulates vesicle localization
  • is a novel downstream signalling mediator during invadopodia formation
  • GIT1, GIT2, ARHGEF7 and RHOJ all colocalised in focal adhesions and depended on each other for their recruitment to focal adhesions
  • multidomain-containing guanine nucleotide exchange factor (GEF) ARHGEF7, that is a positive Hippo pathway regulator
  • GIT1 and ARHGEF7 are involved in Ag-induced chemotaxis, a possible mecanism of concerted action of tyrosine kinases, GIT1/ARHGEF7 proteins, and Ca(2+) in the propagation of signals leading to the regulation of microtubule nucleation in activated mast cells
  • GIT1/ARHGEF7 signaling proteins with PAK1 kinase represent a novel regulatory mechanism of microtubule nucleation in interphase cells
  • ARHGEF6 and ARHGEF7, respectively, are guanine nucleotide exchange factors (activators) for the Rho family small GTP-binding protein family members RAC1 and CDC42
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • forming a complex with G proteins (Rho family GTPases)
  • complex consisting of NOX1, ARHGEF7, and NOXO1 is likely to be a critical step in EGF-induced reactive oxygen species generation
  • forming a complex SCRIB-ARHGEF7-GIT1
  • SLC9A3, SHANK2, and ARHGEF7 form a macromolecular complex when expressed heterologously in mammalian cells
  • FRMPD4 formed a complex with ARHGEF7 via DLG4/Dlg/TJP1 (PDZ) interaction
  • ARHGEF7 forms a complex with cadherin, CTNNB1, and SCRIB at synapses and enhances localized actin polymerization in rat hippocampal neurons
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with NADPH oxidase 1 (NOX1) leading to EGF-induced reactive oxygen species (ROS) generation (PH domain binds to the FAD-binding region of NOX1)
  • interacting with PARVB (involved in reorganization of subsarcolemmal cytoskeletal actin by activation of RAC1 through ARHGEF6 and ARHGEF7 in skeletal muscle)
  • GIT1 and ARHGEF7 form a constitutively associated complex that acts as a scaffold to allow the formation of large multiprotein assemblies that regulate synaptogenesis, cell polarity and cell migration
  • interaction between CALM1 and ARHGEF7 (CALM1 participates in a multi-protein complex involving ARHGEF7 and CBL, which may play a critical role in receptor tyrosine kinase regulation and downstream signaling)
  • INPP5J is a key signalling molecule that regulates dendritic outgrowth through activation of small GTPase signalling via interaction between FRMPD4 and ARHGEF7
  • GRIN3A binds GIT1, a postsynaptic scaffold that assembles actin regulatory complexes, including the RAC1 guanine nucleotide exchange factor ARHGEF7, to promote RAC1 activation in spines
  • ARHGEF7 and GIT1 are required for synaptic GABA(A)R surface stability through the activity of the GTPase RAC1 and downstream effector PAK1
  • is a key component that links the Hippo kinase cassette to YAP1/WWTR1 in response to multiple upstream Hippo pathway activators
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS