Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARHGEF40 contributors: npt/mct - updated : 22-01-2015
HGNC name Rho guanine nucleotide exchange factor (GEF) 40
HGNC id 25516
Location 14q11.2      Physical location : 21.538.526 - 21.558.035
Genatlas name SOLO gene
Synonym name
  • hypothetical protein FLJ10357
  • hypothetical protein LOC55701
  • Synonym symbol(s) FLJ10357, SOLO
    DNA
    TYPE functioning gene
    STRUCTURE 19.52 kb     24 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    24 - 5458 - 1519 - 2005 16143467
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
    Nervous    highly Homo sapiens
     brain    
    Reproductivefemale systemovary  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Muscularmyoblast Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain and muscle
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a C-terminal RhoGEF domain
  • a pleckstrin domain
  • three regions homologous to regions of the zebrafish Quattro protein, which is involved in morphogenetic movements mediated by the actin cytoskeleton
  • HOMOLOGY
    Homologene
    FAMILY
  • guanine exchange factor (GEF) family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nuclear envelope
    text
  • in both myoblasts and neuroblastoma cells, is concentrated around the nucleus
  • basic FUNCTION
  • guanine exchange factor activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SESTD1 associated with TRPC4 and TRPC5 via the channel calmodulin- and inositol 1,4,5-trisphosphate receptor-binding domain
  • interplay between ARHGEF40 and KRT8/KRT18 filaments plays a crucial role in tensile force-induced RHOA activation and consequent actin cytoskeletal reinforcement
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS