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FLASH GENE
Symbol ARHGEF38 contributors: mct - updated : 07-03-2023
HGNC name Rho guanine nucleotide exchange factor 38
HGNC id 25968
Location 4q24      Physical location : 106.473.776 - 106.552.836
Synonym symbol(s) FLJ20184, FLJ43963
DNA
TYPE functioning gene
STRUCTURE 129.95 kb
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 5457 - 777 - 2023 36493769
4 - 1437 - 219 - 2023 36493769
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth     Homo sapiensFetal
Nervousbrain     Homo sapiensFetal
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY GEF family of GTPase regulatory proteins
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • likely having important roles in midface development and being required for proper craniofacial development
  • is likely involved in the regulation of cellular dynamics in an interplay with GAPs, and both GEFs and GAPs are known to control cell migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    higher expression of ARHGEF38 in Prostate cancer (PCa) (in high-grade PCa than the low-grade PCa), than benign prostatic hyperplasia (BPH)
    constitutional       loss of function
    result in craniofacial birth defects such as cleft lip and palate
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a novel biomarker to predict aggressive prostate cancer
  • Therapy target
    ANIMAL & CELL MODELS