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FLASH GENE

Symbol

ARHGEF19

contributors: mct - updated : 24-01-2011

HGNC name	Rho guanine nucleotide exchange factor (GEF) 19
HGNC id	26604

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1p36.13      Physical location : 16.524.598 - 16.539.104
Synonym name	weakly similar to Rho GEF
Synonym symbol(s)	WGEF, FLJ33962

DNA

TYPE	functioning gene
STRUCTURE	14.51 kb     16 Exon(s)

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153213 16 - 3044 - - - 2004 15485661

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive intestine       highly Homo sapiens   liver       highly Homo sapiens Urinary kidney       highly Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a DH-PH domain
	a DBL homology (DH) interacting with N-terminal helices to exclude and prevent activation of Rho GTPases
	a C-terminal SH3 domain

HOMOLOGY

interspecies

homolog to murine Arhgef19

Homologene

FAMILY

Dbl-family proteins

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm
text	preferentially localized at the plasma membrane

basic FUNCTION	activating RHOA, CDC42, and RAC1
	may be involved in the development and functions of intestine, liver, heart and kidney
	regulating adipogenesis through DNA methylation change

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

component of the Wnt-PCP pathway that connects Dishevelled to Rho activation

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

activated by

tyrosine phosphorylation of a blocking helix

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS