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FLASH GENE
Symbol ARHGEF17 contributors: mct - updated : 11-03-2009
HGNC name Rho guanine nucleotide exchange factor (GEF) 17
HGNC id 21726
Location 11q13.4      Physical location : 73.019.662 - 73.080.424
Synonym name
  • cDNA sequence,expressed in brain,>100kDa,related to breakpoint cluster region BCR
  • Rho-specific guanine-nucleotide exchange factor 164 kDa
  • Rho-specific guanine-nucleotide exchange factor 164 kDa
  • Synonym symbol(s) KIAA0337, P164RHOGEF, TEM4, FLJ90019
    DNA
    TYPE functioning gene
    STRUCTURE 60.47 kb     21 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located related to breakpoint cluster region BCR
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    21 - 7830 221.5 2063 - Bloethner (2008)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Nervousbrain    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a calponin-homology (CH) domain
  • a DBL-homology (dh) domain
  • a PH domain
  • one SH2 domain and two SH3 domains
  • one zinc-dependent phorbol-ester and DAG binding domain
  • HOMOLOGY
    intraspecies homolog to breakpoint cluster region BCR
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • coupling tyrosine kinase signals with the activation of the rho/rac gtpases, thus leading to cell differentiation and/or proliferation
  • potential novel tumor suppressor in melanoma (Bloethner 2008)
  • have a crucial role in activating small GTPases by exchanging GDP for GTP and which regulate various cellular functions including actin cytoskeleton organization, activation of kinase cascades, mitogenesis, transcriptional activation, and stimulation of DNA synthesis (Bloethner 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS