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FLASH GENE
Symbol ARHGEF15 contributors: - updated : 03-09-2007
HGNC name Rho guanine nucleotide exchange factor (GEF) 15
HGNC id 15590
Location 17p12      Physical location : 8.213.555 - 8.225.834
Synonym name Rho guanine exchange factor 15
Synonym symbol(s) FLJ13791, KIAA0915, MGC44868, ARGEF15, Vsm-RhoGEF
DNA
TYPE like-sequence
STRUCTURE 12.00 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
KCNAB3 17p13.1 potassium voltage-gated channel, shaker-related subfamily, beta member 3 TRAPPC1 17p13.1 trafficking protein particle complex 1 LIP8 17p13.2 LYST-interacting protein LIP8 GUCY2D 17p13.1 guanylate cyclase 2D, membrane (retina-specific) ALOX15B 17p13.1 arachidonate 15-lipoxygenase, second type LOC388332 17 similar to Gag protein ALOX12B 17p13.1 arachidonate 12-lipoxygenase, 12R type ALOXE3 17p13.1 arachidonate lipoxygenase 3 HES7 17p13.1 hairy and enhancer of split 7 (Drosophila) PER1 17p13.1-p12 period homolog 1 (Drosophila) VAMP2 17p13.1-p12 vesicle-associated membrane protein 2 (synaptobrevin 2) MGC10744 17p13.1 hypothetical protein MGC10744 FLJ20014 17p13.1 hypothetical protein FLJ20014 AURKB 17p13.1 aurora kinase B FLJ34790 17p13.1 hypothetical protein FLJ34790 FLJ22170 17p13.1 hypothetical protein FLJ22170 PFAS 17p13 phosphoribosylformylglycinamidine synthase (FGAR amidotransferase) RANGNRF 17p13 RAN guanine nucleotide release factor ARHGEF15 17p12 Rho guanine nucleotide exchange factor (GEF) 15 ODF4 17p12 outer dense fiber of sperm tails 4 LOC124751 17p13.1 hypothetical protein LOC124751 RPL26 17p13 ribosomal protein L26 LOC390761 17 similar to RIKEN cDNA 9930039A11 gene NDEL1 17p13.1 nudE nuclear distribution gene E homolog like 1 (A. nidulans) MYH10 17p13.1 myosin, heavy polypeptide 10, non-muscle
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Cardiovascularheart   highly
Endocrineadrenal gland   highly
Nervousnervecranial nerve  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
dh (dbl-homology) domain
HOMOLOGY
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • may be forming a complex with G proteins and stimulating Rho-dependent signals
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS