basic FUNCTION
| specific guanine nucleotide exchange factor for RhoA, not for RAC1 or CDC42 |
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involved in neurite retraction through Rho dependent signaling |
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playing a role in SEMA4D-plexin-B1 mediating signal transduction |
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supposed to influence insulin signaling |
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involved in G protein signaling and is a pathway known to play a role in both insulin secretion and action |
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guanine nucleotide exchange factor (GEF) for RHOA, mediating RHOA-dependent responses and determines their spatial distribution |
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mediates RHOA-myosin light chain signaling pathways at cell-cell junctions, functioning in cooperation with TJP1, to regulate the paracellular barrier and the organization of the apical junctional complex and perijunctional actomyosin ring of epithelial cells |
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mediates TJP1-dependent junction assembly and barrier formation in mammary epithelial cells |
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generally regulates apical junctions and junction-associated actomyosin in various epithelial tissues |
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acts as a key determinant of mammalian metabolism and obesity-associated pathologies |
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is a specific guanine nucleotide exchange factors (GEF) for RHOA, which is a critical regulator of actin cytoskeleton dynamics and organization of dendritic spines and inhibitor of spine maintenance |
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is likely to be associated with synaptic membranes and regulation of spine |