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FLASH GENE
Symbol ARHGEF10L contributors: mct - updated : 23/12/2008
HGNC name Rho guanine nucleotide exchange factor (GEF) 10-like
HGNC id 25540
Location 1p36.13      Physical location : 17.866.329 - 18.024.369
Synonym symbol(s) FLJ10521, KIAA1626, GrinchGEF
DNA
TYPE functioning gene
STRUCTURE 158.04 kb     27 Exon(s)
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
38 - 4502 140 1279 - Winkler, Stacey (2008)
isoform 1
27 - 4269 135 1240 - Winkler, Stacey (2008)
lacking an in-frame exon as compared to variant 1, the resulting isoform 2 lacks an internal segment, as compared to isoform 1
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 pharynx   highly
Endocrinepancreas   highly
Respiratoryrespiratory tracttrachea  highly
Urinarybladder    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Dbl homology domain
  • a putative WD40-like domain
  • two predicted transmembrane helices
  • HOMOLOGY
    interspecies homolog to murine Arhgef10l
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION inducing specifically Rho activation and enhancing RhoA-C-specific downstream effects
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    GTP binding
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS