Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARHGEF1 contributors: mct - updated : 20-05-2010
HGNC name Rho guanine nucleotide exchange factor (GEF) 1
HGNC id 681
Location 19q13.2      Physical location : 42.387.266 - 42.411.600
Synonym name
  • mouse Lsc homolog
  • 115-kD protein
  • Synonym symbol(s) LSC, GEF1, LBCL2, p115-RhoGEF, SUB1.5
    DNA
    TYPE functioning gene
    STRUCTURE 24.34 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Map cen - D19S425 - D19S228 - D19S4121 - D19S223 - ARHGEF1 - D19S217 - D19S2100 - D19S418 - qter
    Physical map
    BGALT15 19q13.31 beta galactosyltransferase BGALT15 FLJ10241 19q13.31 hypothetical protein FLJ10241 LOC388543 19 LOC388543 LOC283855 19q13.31 similar to tropomyosin 3 PLEKHA3P1 19 pleckstrin homology domain-containing, family A member 3 pseudogene 1 R29124_1 19q13.31 hypothetical protein R29124_1 CEACAMP3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule pseudogene 3 CEACAM4 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 4 CEACAM7 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 7 CEACAM5 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 5 CEACAM6 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) CEACAM3 19q13.2 carcinoembryonic antigen-related cell adhesion molecule 3 LOC388544 19 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP-1) (Topoisomerase-inhibitor suppressed) MGC42718 19q13.31 hypothetical protein MGC42718 DMRTC2 19q13.31 DMRT-like family C2 RPS19 19q13.2 ribosomal protein S19 CD79A 19q13.2-q13.3 CD79A antigen (immunoglobulin-associated alpha) ARHGEF1 19q13,13 Rho guanine nucleotide exchange factor (GEF) 1 LOC390937 19 similar to Erf RABAC1 19q13.13-q13.2 Rab acceptor 1 (prenylated) ATP1A3 19q13.2 ATPase, Na+/K+ transporting, alpha 3 polypeptide GRIK5 19q13.2 glutamate receptor, ionotropic, kainate 5 FLJ22059 19q13.31 hypothetical protein FLJ22059 POU2F2 19q13.31 POU domain, class 2, transcription factor 2 DEDD2 19q13.31 POU domain, class 2, transcription factor 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 3137 - 879 - 1996 8810315
    29 - 3236 - 912 - 1996 8810315
    29 - 3261 - 927 - 1996 8810315
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   highly
     tonsils   highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Lsc
    Homologene
    FAMILY
    CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • stimulating guanine nucleotide exchange for Rac and Rho
  • playing a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors
  • regulates the migration and adhesion of marginal-zone B cells, and this regulation appears to be required for these cells to contribute to the antibody response to TD antigens
  • role for the exchange factors ARHGEF1 and ARHGEF12 in linking fibronectin signals to downstream RhoA activation
  • regulates integrin-mediated adhesive events at the trailing edge of migrating cells
  • required by T cells for the development of airway hyperreactivity and inflammation
  • with microtubules decide the direction apoptotic cells extrude from an epithelium
  • hematopoietic-restricted signaling molecule that regulates leukocyte migration and integrin-mediated adhesion
  • regulates alpha5beta1-mediated MMP expression by macrophages and its loss by leukocytes leads to pulmonary pathology
  • RhoA guanine exchange factor specifically responsible for AGT–induced activation of RhoA signaling in arterial smooth muscle cells
  • mediates the effects of AGT on vascular tone and blood pressure
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GNA13
  • cell & other
    REGULATION
    activated by AGT signaling in vascular smooth muscle cells, and provided evidence that this activation has a causal role in the development of hypertension
    Other phosphorylated by PKCA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • lungs of Arhgef1-/- mice harbored significantly more leukocytes, increased expression and activity of matrix metalloproteinases (MMPs), airspace enlargement, and decreased lung elastance compared with wild-type lungs