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FLASH GENE

Symbol

ARHGDIG

contributors: mct/npt - updated : 09-7-2009

HGNC name	Rho GDP dissociation inhibitor (GDI) gamma
HGNC id	680

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : 330.605 - 333.003
Synonym name	RhoGDI gamma
Synonym symbol(s)	RGDI3, GDIT, RHOGDI3

DNA

TYPE	functioning gene
STRUCTURE	2.40 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 6 - 942 - 225 pancreas, brain, low in intestine and colon Adra (1997) variant 2 - - 4500 - - pancreas Adra (1997)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain       highly Reproductive male system testis     highly Respiratory lung       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		Hydrophobic
STRUCTURE

motifs/domains

N-terminal 30AAs hydrophobic domain (Adra 1997)

HOMOLOGY

interspecies

homolog to C.elegans F46H6.1

Homologene

FAMILY

Rho GDI family

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular,cytoplasm,cytosolic,ribosome
text	associated with vesicular membranes (Wu 2009)

basic FUNCTION	role in modulating the activation of GTPase by inhibiting the exchange of GDP for GTP
	invasion and metastasis suppressor

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS