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FLASH GENE

Symbol

ARHGDIB

contributors: mct/npt - updated : 19-10-2009

HGNC name	Rho GDP dissociation inhibitor (GDI) beta
HGNC id	679

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	12p12.3      Physical location : 15.094.949 - 15.114.562
Synonym name	GDP-dissociation inhibitor D4
	Rho-GDI beta
Synonym symbol(s)	GDID4, D4, GDIA2, LYGDI, Ly-GDI, RAP1GN1, RHOGDI2

DNA

TYPE	functioning gene
STRUCTURE	19.61 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001175 6 - 1216 NP_001166 - 201 - Adra (1994)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly   spleen       highly   thymus       highly Reproductive male system testis     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic mature hematopoietic

cell lineage	preferentially, in hematopoietic cells
cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies

homolog to Aplysia

Homologene

FAMILY

RHO GDI family

CATEGORY

immunity/defense , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	membrane-bound vesicles

basic FUNCTION	regulating the GDP/GTP exchange reaction of the RHO proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them
	metastasis suppressor gene and its targets, endothelin-1 and Neuromedin U are excellent potential targets for therapeutic intervention in the metastatic cascade (Harding 2007)
	abundantly expressed in haematopoetic cells and possibly plays a role in the onset of apoptosis (Ma 2007)
	suppressor of metastasis in human bladder cancer (Wu 2009)
	inhibit the activation of small GTPases of the Rho family by sequestering the GTPases in the cytosol and blocking activation by guanine nucleotide exchange factors (GEFs) (Wu 2009)
	regulator of Rho family GTPase (Cho 2009)
	involved in gastric tumor growth and metastasis (Cho 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein

endothelin-1 and Neuromedin U are two molecular effectors of ARHGGDIB signaling (Harding 2007)

cell & other

REGULATION

Other

phosphorylation by SRC enhances ARHGDIB metastasis suppression and that loss of SRC relieves metastasis suppression in tumor cells that maintain ARHGDIB expression (Wu 2009)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in many metastatic bladder cancers (Wu 2009) tumoral     --low   is associated with decreased survival for patients with bladder cancer (Theodorescu 2004) tumoral     --low   lack of expression is a frequent feature of Hodgkin lymphoma but that it is not of vital importance for the growth and survival of these cells (Ma 2007)

Susceptibility

Variant & Polymorphism

Candidate gene	useful marker for tumor progression of human gastric cancer (Cho 2009)
Marker
Therapy target

ANIMAL & CELL MODELS