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FLASH GENE
Symbol ARHGDIA contributors: mct/npt - updated : 29-12-2020
HGNC name Rho GDP dissociation inhibitor (GDI) alpha
HGNC id 678
Corresponding disease
NPHS8 nephrotic syndrome, type 8
Location 17q25.3      Physical location : 79.825.597 - 79.829.282
Synonym name Rho GDI 1
Synonym symbol(s) GDIA1, GDIR, RHOGDI, MGC117248, RHOGDI-1, NPHS8
DNA
TYPE functioning gene
STRUCTURE 3.62 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1912 - 204 - 2011 21779026
6 - 1705 - 160 - 2011 21779026
6 - 21259 - 204 - 2011 21779026
7 - 1725 - 337 - 2011 21779026
7 - 1433 - 235 - 2011 21779026
5 - 1972 - 249 - 2011 21779026
7 - 1755 - 235 - 2011 21779026
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Aplysia
homolog to C.elegans F46H6.1
Homologene
FAMILY
  • Rho GDI family
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    text SRC phosphorylation of ARHGDIA induces membrane association (Wu 2009)
    basic FUNCTION
  • regulating the GDP/GTP exchange reaction of the rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them
  • may promote colorectal cancer progression and metastasis by stimulating tumor cell growth and migration (Zhao 2008)
  • rate-limiting and the suppression of RHOA makes it available to stabilize RHOB (Ho 2008)
  • inhibit the activation of small GTPases of the Rho family by sequestering the GTPases in the cytosol and blocking activation by guanine nucleotide exchange factors (GEFs) (Wu 2009)
  • can bind to small GTPases and keep them in a biologically inactive state in cytoplasm, through which it affects actin polymerization and cell motility
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • new cellular pathway in which ATF4 regulates the expression of ARHGDIA that in turn affects Rho GTPase protein levels, and thereby, controls cellular functions as diverse as memory and cell motility
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • negative regulator of the Rho family of GTP-binding proteins (El Marzouk 2007)
  • binds direcly ESR1 and influences ESR1 signaling in the nucleus (El Marzouk 2007)
  • role of ARHGDIA as a CDC42 cycling factor
  • MCAM recruits ARHGDIA through ERM proteins and thus sequesters ARHGDIA from RHOA, which leads to upregulated RHOA activity and increased melanoma cell motility
  • ARHDIA-dependent balance between RHOA and RHOC is a key regulator of cancer cell tumorigenesis
  • XIAP interacted with ARHGDIA via its RING domain and negatively modulated ARHGDIA SUMOylation
  • AGT regulates ARHGDIA stability by SUMOylation and ubiquitination via AT1R activation and thus affects VSMC proliferation and vascular remodeling
  • cell & other
    REGULATION
    Other Src-mediated ARHGDIA phosphorylation is a novel physiological mechanism for regulating Rho GTPase cytosol membrane-cycling and activity (DerMardirossian 2007)
    ASSOCIATED DISORDERS
    corresponding disease(s) NPHS8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    tumoral     --over  
    in metastatic colorectal cancer (Zhao 2008)
    tumoral     --low  
    promotes the development and progression of prostate cancer
    tumoral     --low  
    in human glioma
    tumoral       loss of function
    contributed to the processes of hepatic tumorigenesis, in particular invasion and metastasis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • is a potential prognostic marker for human glioma
  • Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    therapeutic target for human glioma
    cancerdigestiveliver
    potential therapeutic target for HCC
    ANIMAL & CELL MODELS