Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | ARHGDIA | contributors: mct/npt - updated : 29-12-2020 |
HGNC name | Rho GDP dissociation inhibitor (GDI) alpha |
HGNC id | 678 |
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Corresponding disease |
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Location | 17q25.3 Physical location : 79.825.597 - 79.829.282 | ||
Synonym name | Rho GDI 1 | ||
Synonym symbol(s) | GDIA1, GDIR, RHOGDI, MGC117248, RHOGDI-1, NPHS8 |
DNA |
TYPE | functioning gene |
STRUCTURE | 3.62 kb 6 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | provisional |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||
organ(s) |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to Aplysia |
homolog to C.elegans F46H6.1 |
Homologene |
FAMILY |
CATEGORY | regulatory , signaling |
SUBCELLULAR LOCALIZATION | plasma membrane |
intracellular | |
intracellular,cytoplasm,cytosolic | |
intracellular,cytoplasm,cytoskeleton | |
text | SRC phosphorylation of ARHGDIA induces membrane association (Wu 2009) |
basic FUNCTION | |
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CELLULAR PROCESS |
PHYSIOLOGICAL PROCESS |
PATHWAY |
metabolism |
signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Other | Src-mediated ARHGDIA phosphorylation is a novel physiological mechanism for regulating Rho GTPase cytosol membrane-cycling and activity (DerMardirossian 2007) |
ASSOCIATED DISORDERS |
corresponding disease(s) | NPHS8 |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |