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FLASH GENE
Symbol ARHGAP45 contributors: mct - updated : 09-12-2021
HGNC name Rho GTPase activating protein 45
HGNC id 17102
Location 19p13.3      Physical location : -
Synonym name
  • histocompatibility (minor) HA-1
  • Synonym symbol(s) HLA-HA1, KIAA0223, HA-1, HMHA1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE opposite orientation
    STRUCTURE 20.67 kb     23 Exon(s)
    text structure arranged head to tail with ABCA7
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    23 - 4148 - 1152 - 2018 29174013
    23 - 4272
    23 - 4120 - 1140 - 2018 29174013
    22 - 3761 - 1019 - 2018 29174013
    13 - 3309 - 771 - 2018 29174013
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
     tonsils   highly
    Reproductivefemale systemuteruscervix  
    Skin/Tegumentskin    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticmature hematopoietic Homo sapiens
    cell lineage
    cell lines
    fluid/secretion blood, lymph
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies homolog to murine Hmha1 (83.4pc)
    Homologene
    FAMILY
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • may be involved in graft-versus-host disease (GVHD) in transplantation of bone marrow
  • can induce cytotoxic T cells
  • target antigen for immunotherapy of hematological malignancies with no or low risk of GVHD
  • acts as a RHOGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells
  • acts as a Rac-GAP (GTPase-Activating Protein) in endothelial cells, which explains its negative effect on endothelial barrier function
  • is a novel regulator, which contributes to the fine-tuning of the regulation of basal endothelial integrity
  • regulates na
  • ve T-cell deformability and motility
  • ARGHAP45 GAP controls multiple key steps in the life of T and B cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility HA-1 168His variant is associated with reduced susceptibility to primary Sjogren's syndrome
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS