basic FUNCTION
| may be involved in graft-versus-host disease (GVHD) in transplantation of bone marrow |
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can induce cytotoxic T cells |
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target antigen for immunotherapy of hematological malignancies with no or low risk of GVHD |
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acts as a RHOGAP to regulate GTPase activity, cytoskeletal remodeling and cell spreading, which are crucial functions in normal hematopoietic and cancer cells |
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acts as a Rac-GAP (GTPase-Activating Protein) in endothelial cells, which explains its negative effect on endothelial barrier function |
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is a novel regulator, which contributes to the fine-tuning of the regulation of basal endothelial integrity |
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regulates na |
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ve T-cell deformability and motility |
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ARGHAP45 GAP controls multiple key steps in the life of T and B cells |