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FLASH GENE
Symbol ARHGAP25 contributors: mct - updated : 28-11-2018
HGNC name Rho GTPase activating protein 25
HGNC id 28951
Location 2p13.3      Physical location : 68.961.912 - 69.053.948
Genatlas name hypothetical protein KIAA0053
Synonym name
  • epididymis secretory protein Li 308
  • epididymis secretory sperm binding protein
  • Synonym symbol(s) KIAA0053
    DNA
    TYPE functioning gene
    STRUCTURE 116.34 kb     10 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3020 - 645 - 2004 15254788
  • ARHGAP25 Ia
  • 10 - 2957 - 638 - 2004 15254788
  • ARHGAP25 Ib
  • 10 - 2900 - 606 - 2004 15254788
    10 - 2960 - 639 - 2004 15254788
    11 - 2966 - 645 - 2004 15254788
    10 - 2852 - 607 - 2004 15254788
    11 - 2682 - 620 - 2004 15254788
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow    Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one PH domain
  • one Rho-GAP domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound
  • ARHGAP25 is a negative regulator of phagocytosis acting probably via modulation of the actin cytoskeleton
  • ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation
  • likely a critical role of ARHGAP25 in counterbalancing the RAC1-activating effect of nucleotide exchange factors
  • is a relevant negative regulator of leukocyte transendothelial migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS