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FLASH GENE
Symbol ARHGAP24 contributors: mct - updated : 28-04-2015
HGNC name Rho GTPase activating protein 24
HGNC id 25361
Location 4q21.23      Physical location : 86.396.283 - 86.923.822
Synonym name
  • RAC1- and CDC42-specific GTPase-activating protein of 72 kDa
  • filamin-A-associated RhoGAP
  • rhoGAP of 73 kDa
  • Synonym symbol(s) FLJ33877, DKFZP564B1162, FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP
    DNA
    TYPE functioning gene
    STRUCTURE 854.93 kb     8 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 4644 - 748 - 2009 19144823
    8 - 4195 - 653 - 2009 19144823
    8 - 4010 - 663 - 2009 19144823
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text pancreas
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a pleckstrin homology domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    intracellular,nucleus
    text
  • Rac-specific Rho GTPase-activating protein that is recruited to plasma membranes by binding to activated ARF6
  • basic FUNCTION
  • mediator of the well-established antagonism of RAC1 by RHOA that suppresses leading edge protrusion and promotes cell retraction to achieve cellular polarity
  • plays a role in protecting cells against force-induced apoptosis, and this function is mediated by FLNA
  • Rac GTPase-activating protein (GAP), that is a mediator of RHO/ROCK-dependent amoeboid movement of carcinoma cells
  • ARHGAP24 and its close relatives are key regulators that promote the reciprocal inhibitory relationship between RHOA and RAC1 in cell shape changes and the mesenchymal-amoeboid transition in tumour cells
  • may function as a mediator of the regulation of RAC1 by ARF6
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • is an FLNA-binding GTPase-activating protein specific for RAC1
  • is a GAP for RAC1 and a binding partner of FLNA (filamin A), a widely expressed F-actin (filamentous actin)-cross-linking protein that binds many different proteins that are important in cell regulation
  • binds to ARF6 through its pleckstrin homology domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS