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FLASH GENE
Symbol ARHGAP18 contributors: SGE/npt - updated : 03-05-2010
HGNC name Rho GTPase activating protein 18
HGNC id 21035
Location 6q22.33      Physical location : 129.898.240 - 130.031.370
Synonym name MacGAP protein
Synonym symbol(s) MacGAP, bA307O14.2, FLJ25728, MGC126757, MGC138145
DNA
TYPE functioning gene
STRUCTURE 133.13 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389426 6 LOC389426 LOC391969 6 similar to ribosomal protein S4, X-linked LOC389427 6 similar to MGC32805 protein THSD2 6q22.33 thrombospondin, type I, domain 2 RNF146 6q22.1-q22.33 ring finger protein 146 ECHDC1 6q22.33 enoyl Coenzyme A hydratase domain containing 1 LOC246737 6q23.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene LOC389428 6 similar to ribosomal protein L5; 60S ribosomal protein L5 KIAA0408 6q22.33 KIAA0408 LOC389429 6 similar to RIKEN cDNA 2310057J18 MRPS17P5 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5 PTPRK 6q22.2-q22.3 protein tyrosine phosphatase, receptor type, K LOC391970 6 similar to eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) LAMA2 6q22-q23 laminin, alpha 2 (merosin, congenital muscular dystrophy) LOC338470 6q22-q23 mesoderm specific transcript homolog (mouse) pseudogene ARHGAP18 6q23.1 Rho GTPase activating protein 18 C6orf191 6q23.1 chromosome 6 open reading frame 191 L3MBTL3 6q23 l(3)mbt-like 3 (Drosophila) SAMD3 6q23.1 sterile alpha motif domain containing 3 KIAA1913 6q23.1 KIAA1913 EPB41L2 6q23 erythrocyte membrane protein band 4.1-like 2 AKAP7 6q22-q23 a kinase (PRKA) anchor protein 7 ARG1 6q22.3-q23.1 arginase, liver CRSP3 6q22.33-q24.1 cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa ENPP3 6q22 ectonucleotide pyrophosphatase/phosphodiesterase 3 OR2A4 6q33-q35 olfactory receptor, family 2, subfamily A, member 4 ENPP1 6q22-q23 ectonucleotide pyrophosphatase/phosphodiesterase 1 CTGF 6q23.1 connective tissue growth factor MOXD1 6q22-q23 monooxygenase, DBH-like 1 STX7 6q22.3-q24 syntaxin 7 TAR3 6q23.1 trace amine receptor 3 GPR102 6q23.2 G protein-coupled receptor 102 TA4 6q23.1 trace amine receptor 4 PNR 6q23 putative neurotransmitter receptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3503 - 663 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Lymphoid/Immunethymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a RhoGAP domain
  • HOMOLOGY
    interspecies homolog to murine Arhgap18 (85.3pc)
    homolog to rattus Arhgap18 (85.8pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    text
  • localized to the leading edge during cell spreading and migration
  • basic FUNCTION
  • Rho GTPase-activating protein that modulates cell signaling
  • GTPase activator for the Rho-type GTPases, by converting them to an inactive GDP-bound state
  • required for the polarization of cells for migration and is one of the crucial factors for the regulation of RHOA for the control of cell shape, spreading, and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • GTP binding
  • protein
  • interacting with MPHOSPH6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    suppressed the activity of RHOoA and disrupted stress fiber formation
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS