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FLASH GENE
Symbol ARHGAP18 contributors: SGE/npt - updated : 03-05-2010
HGNC name Rho GTPase activating protein 18
HGNC id 21035
Location 6q22.33      Physical location : 129.898.240 - 130.031.370
Synonym name MacGAP protein
Synonym symbol(s) MacGAP, bA307O14.2, FLJ25728, MGC126757, MGC138145
DNA
TYPE functioning gene
STRUCTURE 133.13 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3503 - 663 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid    
Lymphoid/Immunethymus    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a RhoGAP domain
  • HOMOLOGY
    interspecies homolog to murine Arhgap18 (85.3pc)
    homolog to rattus Arhgap18 (85.8pc)
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    text
  • localized to the leading edge during cell spreading and migration
  • basic FUNCTION
  • Rho GTPase-activating protein that modulates cell signaling
  • GTPase activator for the Rho-type GTPases, by converting them to an inactive GDP-bound state
  • required for the polarization of cells for migration and is one of the crucial factors for the regulation of RHOA for the control of cell shape, spreading, and migration
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor, nucleotide,
  • GTP binding
  • protein
  • interacting with MPHOSPH6
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    suppressed the activity of RHOoA and disrupted stress fiber formation
    Susceptibility to schizophrenia
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS