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FLASH GENE
Symbol ARHGAP17 contributors: mct - updated : 10-12-2013
HGNC name Rho GTPase activating protein 17
HGNC id 18239
Location 16p12.1      Physical location : 24.930.713 - 25.026.675
Genatlas name nadrin
Synonym name
  • Homo sapiens homolog of rat nadrin (RICH1), mRNA
  • RhoGAP interacting with CIP4 homologs 1 neuron-associated
  • rat nadrin homolog (neuron-associated developmentally regulated protein)
  • developmentally regulated protein
  • neuron-associated developmentally regulated protein
  • Synonym symbol(s) RICH1, NADRIN, WBP15, MST066, MST110, MSTP066, MSTP110, FLJ10308, FLJ13219
    DNA
    TYPE functioning gene
    STRUCTURE 95.99 kb     20 Exon(s)
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 3246 87.5 803 heart, placenta, higher muscle, lower brain 2000 10967100
  • an N-terminal domain that shares homology with endophilins, a central RHOGAP domain and a C-terminal domain containing 4 proline-rich sequences
  • 9 - - 25.7 226 heart, placenta 2000 10967100
    an N-terminal domain that shares homology with endophilins
    20 splicing 3480 95.4 881 - 2000 10967100
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   highly
    Nervousbrain     Homo sapiens
    Reproductivefemale systemplacenta  highly
     female systemuterus  moderately
     female systembreastmammary gland moderately
    Respiratoryrespiratory tracttrachea  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticplatelet Homo sapiens
    Nervousastrocyte Homo sapiens
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text placenta, umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal BAR domain, controling Nadrin-GAP activity and acting as a guidance domain to direct this GAP to its substrate at the plasma membrane
  • a GAP domain (GTPase activating protein)
  • a potential coiled-coil domain
  • a succession of 29 Glu
  • a serine/threonine/proline-rich domain,
  • a SH3-binding motif
  • HOMOLOGY
    interspecies ortholog to rattus Arhgap17 (88pc)
    ortholog to murine Arhgap17 (81.5pc)
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane,junction,tight
        intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • regulating actin filament reorganization and neurons differentiation (regulation of calcium dependent exocytosis)
  • GTP activating protein for CDC42 and RAC1
  • involved in regulation of Cdc42, being necessary for maintenance of tight junctions
  • maintaining tight junctions integrity by the coordinate regulation of Cdc42 and by linking specific components of the TJ to intracellular protein trafficking, when binding to AMOT
  • Acting as an aminoacyl-tRNA ligase
  • catalyzing GTP hydrolysis on CDC42 and RAC1, but not on RHOA
  • RHOGAP regulating cytoplasmic protein explored in the central nervous system
  • controls RHOA-mediated stress fibre and focal adhesion formation
  • role of NADRIN, in the morphological differentiation of astrocytes
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • formed a complex with ezrin-radixin-moesin (ERM) protein by interacting with ERM-binding phosphoprotein 50 via its C-terminal DLG4/TJP1-binding motif
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • TRIP10
  • coiled-coil domain of AMOT
  • AMOT functions downstream of NF2 and upstream of ARHGAP17, a small GTPase Activating Protein, as a positive regulator of RAC1
  • critical role for Nadrin in the regulation of RHOA, CDC42 and RAC1 in platelets and thus for platelet adhesion and aggregation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS