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FLASH GENE
Symbol ARHGAP15 contributors: npt/ - updated : 29-08-2003
HGNC name Rho GTPase activating protein 15
HGNC id 21030
Location 2q22.3      Physical location : 143.886.898 - 144.525.920
Synonym name uncharacterized bone marrow protein BM046
Synonym symbol(s) BM046
DNA
TYPE functioning gene
STRUCTURE 638.96 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
UBBP1 17p12-p11.2 ubiquitin B pseudogene 1 KIAA1679 2q21-q22 KIAA1679 protein HNMT 2p14-q21.3 histamine N-methyltransferase LOC150498 2q22.1 similar to epsilon isoform of 14-3-3 protein LOC339744 2q22.1 similar to speckle-type POZ protein NXPH2 2q21.1 neurexophilin 2 LOC129560 2q22.1 similar to Adenosylhomocysteinase (S-adenosyl-L-homocysteine hydrolase) (AdoHcyase) MRPS18BP2 6q22.33 mitochondrial ribosomal protein S17 pseudogene 5 LRP1B 2q21.2 low density lipoprotein-related protein 1B (deleted in tumors) KYNU 2q22.1 kynureninase (L-kynurenine hydrolase) ARHGAP15 2q22.3 Rho GTPase activating protein 15 FLJ11753 2q22.3-q23.1 hypothetical protein FLJ11753 LOC387627 2 hypothetical gene supported by NM_014118 ZFHX1B 2q22 zinc finger homeobox 1b LOC200583 2q23.2-q23.3 similar to Polyadenylate-binding protein 1 (Poly(A)-binding protein 1) (PABP 1) ACVR2 2q22.2-q23.3 activin A receptor, type II ORC4L 2q22-q23 origin recognition complex, subunit 4-like (yeast) MBD5 2q23.2 methyl-CpG binding domain protein 5 DKFZP566F2124 2q23.3 DKFZP566F2124 protein UBBP3 2q22.3 ubiquitin B pseudogene 3 LOC344172 2q23.3 similar to ubiquitin specific protease 8 LOC391451 2 similar to Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) KIF5C 2q22.3-q32 kinesin family member 5C LOC151276 2q23.3 thioredoxin 1 pseudogene 1 LOC130576 2q23.3 hypothetical protein LOC130576 MGC52057 2q23.3 hypothetical protein MGC52057 CL25022 2q23.3 hypothetical protein CL25022
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 1774 54.4 475 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a pleckstrin homology (PH) domain
  • a RhoGAP domain
  • a novel motif N-terminal to the GAP domain
  • this novel motif was found to be responsible for nucleotide-independent Rac1 binding
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • potential regulator of Rac1
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS