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FLASH GENE
Symbol ARHGAP12 contributors: mct - updated : 28-11-2018
HGNC name Rho GTPase activating protein 12
HGNC id 16348
Location 10p11.22      Physical location : 32.095.224 - 32.217.770
Synonym symbol(s) FLJ10971, FLJ20737, FLJ21785, FLJ45709, DKFZp779N2050
DNA
TYPE functioning gene
STRUCTURE 123.48 kb     20 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC347806 10p12.1 similar to hypothetical protein FLJ10817 LOC340913 10p12.1 similar to breast cancer antigen NY-BR-1 LOC338617 10p12.1 similar to HSPC132 FLJ44037 10p12.1 FLJ44037 protein RAB18 10p12.1 RAB18, member RAS oncogene family C10orf48 10p12.1 chromosome 10 open reading frame 48 FLJ10817 MRPS21P5 10p12.1 mitochondrial ribosomal protein S21 pseudogene 5 FLJ32798 LOC389945 10 similar to zinc finger protein 12 LOC340917 10p12.1 similar to laminin-binding protein WAC 10p12.1-p11.2 similar to laminin-binding protein NMA 10p12.3-p11.2 similar to laminin-binding protein MGC45541 10p12.1 hypothetical protein MGC45541 LOC256457 10p12.1 similar to 60S ribosomal protein L21 MGC33408 10p12.1 similar to lysozyme C-1 (1,4-beta-N-acylmuramidase C, EC 3.2.1.17) LOC387647 10 hypothetical gene supported by BC014163 SVIL 10p11.2 supervillin bA192N10.2 10q11.1 cell division control protein CKS1 pseudogene KIAA1462 10p12.1 KIAA1462 FLJ10486 10p12.1 hypothetical protein FLJ10486 LOC389946 10 similar to G1/S-specific cyclin D3 MAP3K8 10p11.2 mitogen-activated protein kinase kinase kinase 8 LOC119180 10p11.23 lysozyme 2 LOC143110 10p11.23 similar to supervillin isoform 2; membrane-associated F-actin binding protein p205; archvillin LOC387648 10 similar to supervillin isoform 2; membrane-associated F-actin binding protein p205; archvillin LOC220929 10p11.23 hypothetical protein LOC220929 TCF8 10p11.2 transcription factor 8 (represses interleukin 2 expression) LOC387649 10 LOC387649 ARHGAP12 10pter-cen Rho GTPase activating protein 12 KIF5B 10p11.2 kinesin family member 5B LOC387650 10 hypothetical gene supported by BC000689; NM_021130; NR_000030 EPC1 10p11 enhancer of polycomb homolog 1, (Drosophila) FLJ32762 FLJ13031 ITGB1 10p11.2 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) LOC340933 10p11.23 similar to 60S ribosomal protein L7a (Surfeit locus protein 3) (PLA-X polypeptide) NRP1 10p12 neuropilin 1 PARD3 10p11.23 par-3 partitioning defective 3 homolog (C. elegans) CUL2 10p11.2-p11.1 cullin 2 CREM 10p12.1-p11.1 cAMP responsive element modulator C10orf9 10p11.22 chromosome 10 open reading frame 9 CX40.1 10p11.22 connexin40.1 FZD8 10p11.22 frizzled homolog 8 (Drosophila) LOC389947 10 similar to ribosomal protein L7
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 splicing - - 816 heart : highly,lung,kidney,liver brain,pancreas 2008 18504429
  • two polyadenylation signals
  • 18 exons (lacking exons 8 and 9)
  • 20 splicing 4172 - 846 kidney, liver, brain, pancreas (higher than variant a), lung 2008 18504429
  • two polyadenylation signals
  • 20 exons (having exons 8 and 9)
  • 17 - 4874 - 769 - 2008 18504429
    19 - 4964 - 799 - 2008 18504429
    18 - 5015 - 816 - 2008 18504429
    19 - 5090 - 841 - 2008 18504429
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainhindbraincerebellum  
     brainlimbic systemhippocampus specific Homo sapiens
     braindiencephalonamygdala  
    Reproductivemale systemtestis   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    cell lineage
    cell lines tumor cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a SH3 domain
  • two WW domain
  • a PH domain and a rhoGAP domain
  • one zinc-dependent phorbol-ester and DAG binding domain
  • HOMOLOGY
    interspecies homolog to Drosophila cg18856
    homolog to C.elegans r10h10.1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • stimulating the intrinsic GTP hydrolysis activity of Rho family proteins
  • ARHGAP12, ARHGAP25 and SH3BP1 are responsible for GTPase inactivation
  • is a synaptic RhoGAP that regulates excitatory synaptic structure and function during development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS