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FLASH GENE
Symbol ARFIP2 contributors: mct - updated : 27-10-2011
HGNC name ADP-ribosylation factor interacting protein 2
HGNC id 17160
Location 11p15.4      Physical location : 6.496.927 - 6.502.595
Synonym name
  • arfaptin 2
  • partner of RAC1 (arfaptin 2)
  • protein POR1
  • Synonym symbol(s) POR1, FLJ18046, FLJ18697, FLJ99239
    DNA
    TYPE functioning gene
    STRUCTURE 6.80 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 3725 37.7 341 - 1997 9312003
    6 - 3505 - 256 - 1997 9312003
    7 - 3624 - 303 - 1997 9312003
    8 - 3864 - 374 - 1997 9312003
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a BAR (Bin/Amphiphysin/Rvs) domain, which participates in membrane deformation
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY signaling , transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text
  • associate with trans-Golgi membranes (recruited onto trans-Golgi membranes by interacting with ARL1, and capable of inducing membrane deformation via its BAR domain)
  • basic FUNCTION
  • involved in regulating huntingtin protein aggregation, possibly by impairing proteasome function
  • had a neuroprotective effect on striatal neurons when phosphorylated by AKT1, and inhibits PolyQ-huntingtin-induced toxicity by rescuing proteasome impairment
  • may have the ability to deform membranes or amplify and stabilize the membrane curvature
  • potentially involved in distinct transport processes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RAC1
  • interacts with all Arf proteins examined and an Arf-like protein, ARL1
  • binding partners of the ARF small GTPases
  • interact with ARL1 through its BAR domain-containing region and compete for ARL1 binding with GOLGA1 and GOLGA4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS