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FLASH GENE
Symbol ARFGAP3 contributors: mct/npt - updated : 11-05-2011
HGNC name ADP-ribosylation factor GTPase activating protein 3
HGNC id 661
Location 22q13.2      Physical location : 43.192.531 - 43.253.408
Synonym name ADP-ribosylation factor GTPase activating protein 1
Synonym symbol(s) ARFGAP1
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 60.88 kb     16 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
SEPT3 22q13.2 septin 3 MGC26816 22q13.31 hypothetical protein MGC26816 NAGA 22q13.2 N-acetylgalactosaminidase, alpha- LOC150368 22q13.31 hypothetical protein LOC150368 LOC91689 22q13.31 hypothetical gene supported by AL449243 NDUFA6 22q13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa LOC246785 22q13.2 PTD004 pseudogene CYP2D8P2 22q11.22-q11.23 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2 CYP2D8P1 22q13.2-q13.31 cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 1 TCF20 22q13.3 transcription factor 20 (AR1) LOC388906 22 hypothetical gene supported by BC039496 LOC150371 22q13.31 hypothetical LOC150371 NFAM1 22q13.31 NFAT activation molecule 1 SERHL 22q13.2-q13.31 serine hydrolase-like CGI-96 22q13.2-q13.31 CGI-96 protein dJ222E13.1 22q13 kraken-like dJ222E13.2 22q13.31 similar to CGI-96 PDIP46 RNU12P 22 RNA, U12 small nuclear pseudogene DIA1 22q13.2 diaphorase (NADH) (cytochrome b-5 reductase) A4GALT 22q13.2 alpha 1,4-galactosyltransferase LOC388907 22 similar to ribosomal protein L5; 60S ribosomal protein L5 LOC391337 22 similar to hypothetical protein ARFGAP3 22q13.2-q13.3 ADP-ribosylation factor GTPase activating protein 3 PACSIN2 22q13.31 protein kinase C and casein kinase substrate in neurons 2 TTLL1 22q13.1 tubulin tyrosine ligase-like 1 BIK 22q13.31 BCL2-interacting killer (apoptosis-inducing) MT 22q13.31 malonyl-CoA:acyl carrier protein transacylase (malonyltransferase) BZRP 22q13.31 benzodiazapine receptor (peripheral) KIAA0153 22q13.31 benzodiazapine receptor (peripheral) SCUBE1 22q13.2-q13.3 signal peptide, CUB domain, EGF-like 1 DKFZp547I094 22q13.31 hypothetical protein DKFZp547I094 LOC388908 22 similar to chromosome 22 open reading frame 1; adult brain protein 239 FLJ23588 22q13.1-q13.33 CAP-binding protein complex interacting protein 1
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 2851 56 516 - 2000 10704287
15 - 2719 - 472 - 2000 10704287
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticthymus   highly
Endocrineneuroendocrine   highly
Nervousbrain   highly
Reproductivemale systemtestis  highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Lymphoid    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text thymus, brain, lung highly
PROTEIN
PHYSICAL PROPERTIES Hydrophilic
STRUCTURE
motifs/domains
  • a GAP domain that includes a GATA-1-type zinc finger motif
  • a multiple phosphorylation sites of protein kinase C
  • a ARFGAP domain
  • HOMOLOGY
    interspecies homolog to Drosophila CG6838
    homolog to C.elegans F07F6.4
    ortholog to of yeast Glo3p
    Homologene
    FAMILY
    CATEGORY regulatory , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    text
  • localizing to the Golgi complex and to perinuclear region
  • Golgi localization depends on both a central basic stretch and a carboxy-amphipathic motif
  • basic FUNCTION
  • regulating hydrolysis of ARF1 and involved in intracellular traffic of proteins and vesicular transport
  • function with ARFGAP2 in COP I traffic
  • control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor ARF1 at the Golgi apparatus
  • ARFGAP1, ARFGAP2, and ARFGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport
  • follow the dynamic behavior of coatomer upon stimulation of vesicle budding
  • key components of the COPI coat lattice and are necessary for proper vesicle formation
  • ARFGAP2 and ARFGAP3 seem to be essential for the formation of the vesicle promoting coat lattice
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    induced by phospholipids
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS