Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARFGAP2 contributors: mct/npt - updated : 13/09/2008
HGNC name ADP-ribosylation factor GTPase activating protein 2
HGNC id 13504
Location 11p11.2      Physical location : 47.185.853 - 47.198.419
Synonym name
  • zinc finger protein 289, ID1 regulated
  • GTPase-activating protein ZNF289
  • putative protein product of Nbla10535
  • Synonym symbol(s) IRZ, ZFP289, ZNF289, FLJ14576, Nbla10535, FLJ26000
    DNA
    TYPE functioning gene
    STRUCTURE 12.57 kb     16 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 2803 56 521 - Watson (2004)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   highly
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain   highly
    Reproductivefemale systembreast   
     male systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    reproductivemammary gland
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • zinc finger domain
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to Drosophila aef1
    homolog to yeast gcs-1
    homolog to C.elegans C55B7.12
    ortholog to murine Znf289
    ortholog to yeast Glo3p
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus,nucleolus
    text predominantly cytoplasmic
    basic FUNCTION
  • mediator of ID1 induced proliferation pathway in mammary epithelial cells
  • ARFGAP2 and ARFGAP3 are coat protein-dependent ArfGAPs
  • control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor ARF1 at the Golgi apparatus
  • ARFGAP1, ARFGAP2, and ARFGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport
  • function with ARFGAP2 in COP I traffic
  • follow the dynamic behavior of coatomer upon stimulation of vesicle budding
  • ARFGAP2 and ARFGAP3 seem to be essential for the formation of the vesicle promoting coat lattice
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
    cell & other
    REGULATION
    activated by ID1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS