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FLASH GENE
Symbol ARFGAP1 contributors: mct - updated : 11-05-2011
HGNC name ADP-ribosylation factor GTPase activating protein 1
HGNC id 15852
Location 20q13.33      Physical location : 61.904.164 - 61.921.141
Synonym name
  • GAP protein
  • ARF1-directed GTPase- activating protein
    • Synonym symbol(s) ARF1GAP, FLJ10767, bA261N11.3, MGC39924, HRIHFB2281
    DNA
    TYPE like-sequence
    STRUCTURE 17.00 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3250 44 406 - Huber
    - splicing 3274 - 414 - Huber
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    Respiratoryrespiratory tracttrachea  highly
    Skin/Tegumentskin   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an amino-terminal 115-amino acid catalytic domain
  • zinc finger domain
  • Arf-GAP domain
    • conjugated MetalloP
    mono polymer monomer
    HOMOLOGY
    interspecies ortholog to murine Arfgap1
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the activation of the GTPase activity of ARF
  • promoting hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles
  • control guanosine triphosphate (GTP) hydrolysis on the small G protein ADP-ribosylation factor ARF1 at the Golgi apparatus
  • involved in retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER) by regulating the uncoating of coat protein I (COPI)-coated vesicles
  • ARFGAP1, ARFGAP2, and ARFGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport
  • role of ARFGAP1 in AP-2-regulated endocytosis that has mechanistic parallels with its roles in COPI transport
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the COPI complex
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
  • binding to COP/sat proteins, CK.DELR1 and RNP24
  • interacts with ADP-ribosylation factor 1 (ARF1)
    • cell & other
    REGULATION
    activated by phosphoinositids
    inhibited by phosphatidylcholine
    RNP24
    Other regulated by CHKA
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS