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FLASH GENE
Symbol ARF1 contributors: mct - updated : 24-08-2014
HGNC name ADP-ribosylation factor 1
HGNC id 652
Location 1q42.13      Physical location : 228.270.360 - 228.286.912
DNA
TYPE functioning gene
STRUCTURE 16.53 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LOC343363 1q42.13 similar to basic transcription factor 3 LOC391171 1 similar to beta-tubulin 4Q LOC255208 1q42.13 HSA1q42.3 beta-tubulin 4Q pseudogene MGC42493 1q42.13 hypothetical protein MGC42493 MRP63P2 1q42.13 mitochondrial ribosomal protein 63 pseudogene 2 MGC15634 1q42.13 hypothetical protein MGC15634 FLJ12517 1q42.13 hypothetical protein FLJ12517 IMAGE3451454 1q42.13 SVAP1 protein MPN2 1q42.13 marapsin 2 WNT9A 1q42 wingless-type MMTV integration site family, member 9A LOC340346 1q42.13 hypothetical gene supported by AK093729; AK096776; AL117642 LOC391173 1 similar to capicua homolog WNT3A 1q42 wingless-type MMTV integration site family, member 3A DKFZp434C0923 1q42.13 hypothetical protein DKFZp434C0923 ARF1 1q42 ADP-ribosylation factor 1 C1orf35 1q42.13 chromosome 1 open reading frame 35 MRPL55 1p36.3 mitochondrial ribosomal protein L55 LOC391174 1 similar to hypothetical protein FLJ22875 GUK1 1q32-q41 guanylate kinase 1 GJA12 1q41-q42 gap junction protein, alpha 12, 47kDa LOC200205 1q42.13 hypothetical protein LOC200205 FLJ14124 1q42.13 hypothetical protein FLJ14124 KIAA1639 1q42.13 KIAA1639 protein TRIM11 1q42.13 tripartite motif-containing 11 TRIM17 1q42 tripartite motif-containing 17 HIST3H3 1q42 histone 3, H3 LOC391175 1 similar to 60S ribosomal protein L23a HIST3H2A 1q42.13 histone 3, H2a HIST3H2BB 1q42.13 histone 3, H2bb HIST3H2BA 1 histone 3, H2ba LOC149603 1q42.13 hypothetical protein LOC149603 FLJ31401 1q42.13 hypothetical protein FLJ31401 LOC388750 1 similar to Ferritin heavy chain (Ferritin H subunit) ARHU 1q42.11-q42.3 ras homolog gene family, member U
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2020 20.6 181 - 2005 16308272
5 - 1998 - 181 - 2005 16308272
5 - 1986 - 181 - 2005 16308272
5 - 1901 - 181 - 2005 16308272
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 salivary gland   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • guanine nucleotide dependent protein activator of cholera toxin, involved in the coating of vesicles that bud from Golgi compartments and vesicular trafficking,
  • through interaction with ARF exchange factor
  • playing a crucial role in protein trafficking
  • active during mitosis and this activity is required for mitotic Golgi fragmentation
  • with ARF6, load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix
  • monomeric GTPases that is important regulator of membrane traffic
  • plays an essential role in regulating asymmetric cell division in female meiosis
  • modulator of VEGF-stimulated NO(nitric oxide) release and signaling in endothelial cells
  • ARF1 and AGAP2 have key trafficking functions at the interface between early endosomes and the TGN
  • ARF1, ARF4 regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment
  • required for maintenance of Golgi architecture and for vesicular trafficking, including the copper-responsive trafficking of ATP7A
  • essential cofactor for TP53-independent MYC-induced apoptosis
  • role in controlling cell proliferation, dependent on its ability to regulate RB1/E2F1 activity and gene expression for enhanced proliferation and breast cancer progression
  • regulates Golgi traffic and is activated by two related types of guanine nucleotide exchange factor (GEF)
  • ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
  • concerted action of of ARF1, ARHGAP21, and Cdc42 to regulate fluid phase endocytosis in mammalian cells ('
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • low molecular weight GTP binding
  • interacting with PRKCABP, ARFGAP1, which hydrolyzes GTP and binding DDEF2 thus, regulates its function
  • binds DDEF2
  • interaction with IQSEC3 (may play an important role in the secretion pathway as a GEF for ARF1)
  • dynein and microtubule-dependent Golgi positioning is regulated by ARF1-, coatomer-, and ARHGAP21-dependent CDC42 signaling
  • ARL1 acts to direct a trans-Golgi-specific ARF1 GEF, and hence active ARF1, to the trans side of the Golgi (PMID;
  • ARAP1 regulates the ring size of circular dorsal ruffles through ARF1 and ARF5
  • ELMOD2 exhibited GAP activity against ARL2, ARL3, and ARF1
  • interaction of PLEKHA3 with ARF1 and PI4P at a membrane surface
  • concerted action of ARF1, ARHGAP21, and CDC42 to regulate fluid phase endocytosis
  • ARF1/TBCE-mediated cross-talk that coordinates COPI formation and tubulin polymerization at the Golgi
  • cell & other
    REGULATION
    activated by by cell membrane binding of a self-folding N-terminal domain
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS