Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ARF1 contributors: mct - updated : 24-08-2017
HGNC name ADP-ribosylation factor 1
HGNC id 652
Location 1q42.13      Physical location : 228.270.360 - 228.286.912
DNA
TYPE functioning gene
STRUCTURE 16.53 kb     5 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 2020 20.6 181 - 2005 16308272
5 - 1998 - 181 - 2005 16308272
5 - 1986 - 181 - 2005 16308272
5 - 1901 - 181 - 2005 16308272
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 salivary gland   highly
Reproductivefemale systemplacenta  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • small GTPase superfamily
  • ADP-ribosylation factors (ARF) family
  • CATEGORY enzyme , receptor membrane G
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • guanine nucleotide dependent protein activator of cholera toxin, involved in the coating of vesicles that bud from Golgi compartments and vesicular trafficking,
  • through interaction with ARF exchange factor
  • playing a crucial role in protein trafficking
  • active during mitosis and this activity is required for mitotic Golgi fragmentation
  • with ARF6, load GTP in a membrane-curvature-dependent manner and stabilize, or further facilitate, changes in membrane curvature through the insertion of an amphipathic helix
  • monomeric GTPases that is important regulator of membrane traffic
  • plays an essential role in regulating asymmetric cell division in female meiosis
  • modulator of VEGF-stimulated NO(nitric oxide) release and signaling in endothelial cells
  • ARF1 and AGAP2 have key trafficking functions at the interface between early endosomes and the TGN
  • ARF1, ARF4 regulate morphology and intraorganellar traffic in the endoplasmic reticulum-Golgi intermediate compartment
  • required for maintenance of Golgi architecture and for vesicular trafficking, including the copper-responsive trafficking of ATP7A
  • essential cofactor for TP53-independent MYC-induced apoptosis
  • role in controlling cell proliferation, dependent on its ability to regulate RB1/E2F1 activity and gene expression for enhanced proliferation and breast cancer progression
  • regulates Golgi traffic and is activated by two related types of guanine nucleotide exchange factor (GEF)
  • ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus
  • concerted action of of ARF1, ARHGAP21, and Cdc42 to regulate fluid phase endocytosis in mammalian cells
  • GBF1 and ARF1 function in vesicular trafficking, lipid homoeostasis and organelle dynamics
  • ARF1 small G protein and its activator GBF1 are important regulators of Golgi organization, maintaining its morphology and function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
  • AMPK-GBF1-ARF1 signaling is involved in the regulation of Golgi fragmentation during mitosis
  • a component
  • CYTH2-ARF1 regulates formation of podosomes by inhibition of RHOA/myosin-II and promotion of actin core assembly
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • low molecular weight GTP binding
  • interacting with PRKCABP, ARFGAP1, which hydrolyzes GTP and binding DDEF2 thus, regulates its function
  • binds DDEF2
  • interaction with IQSEC3 (may play an important role in the secretion pathway as a GEF for ARF1)
  • dynein and microtubule-dependent Golgi positioning is regulated by ARF1-, coatomer-, and ARHGAP21-dependent CDC42 signaling
  • ARL1 acts to direct a trans-Golgi-specific ARF1 GEF, and hence active ARF1, to the trans side of the Golgi (PMID;
  • ARAP1 regulates the ring size of circular dorsal ruffles through ARF1 and ARF5
  • ELMOD2 exhibited GAP activity against ARL2, ARL3, and ARF1
  • GBF1 recruitment requires ARF-GDP myristoylation-dependent interactions suggesting regulation of a membrane-bound factor
  • interaction of PLEKHA3 with ARF1 and PI4P at a membrane surface
  • concerted action of ARF1, ARHGAP21, and CDC42 to regulate fluid phase endocytosis
  • ARF1/TBCE-mediated cross-talk that coordinates COPI formation and tubulin polymerization at the Golgi
  • . physical interaction between GBF1 and RHOT1, RHOT2, and also between the active GTP-bound form of ARF1 and RHOT1, RHOT2 (
    cell & other
    REGULATION
    activated by by cell membrane binding of a self-folding N-terminal domain
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS