basic FUNCTION
| having DNA binding activity |
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regulates chemotaxis and adhesion-dependent processes in neutrophils |
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a GTPase activating protein for RHO and ARF family GTPases, that is one of many phosphoinositide 3-OH kinase (PI3K) effectors |
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regulates lymphatic vascular development |
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despite a critical role for ARAP3 in embryonic vascular development, its loss in endothelial cells minimally impacts HSCs in adult bone marrow |
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is unique for its dual specificity GAPs (GTPase-activating protein) activity for ARF6 and RHOA regulated by phosphatidylinositol 3,4,5-trisphosphate and a small GTPase RAP1-GTP and is involved in regulation of cell shape and adhesion |