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FLASH GENE
Symbol ARAP3 contributors: mct - updated : 23-05-2018
HGNC name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
HGNC id 24097
Location 5q31.3      Physical location : 141.032.968 - 141.061.800
Synonym name
  • phosphoinositide binding protein
  • ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein
  • centaurin, delta 3
  • Synonym symbol(s) FLJ21065, DRAG1, CENTD3
    DNA
    TYPE functioning gene
    STRUCTURE 28.83 kb     33 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    33 - 5281 - 1544 - 2016 27311713
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunethymus    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Epithelial    
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a Ras association (RA) domain that interacts with the small G-protein Rap1
  • a sterile alpha motif (SAM) domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton
    basic FUNCTION
  • having DNA binding activity
  • regulates chemotaxis and adhesion-dependent processes in neutrophils
  • a GTPase activating protein for RHO and ARF family GTPases, that is one of many phosphoinositide 3-OH kinase (PI3K) effectors
  • regulates lymphatic vascular development
  • despite a critical role for ARAP3 in embryonic vascular development, its loss in endothelial cells minimally impacts HSCs in adult bone marrow
  • is unique for its dual specificity GAPs (GTPase-activating protein) activity for ARF6 and RHOA regulated by phosphatidylinositol 3,4,5-trisphosphate and a small GTPase RAP1-GTP and is involved in regulation of cell shape and adhesion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • signaling pathway that controls angiogenesis immediately downstream of PIK3CA through ARAP3 to the RHO and ARF family of small GTPases
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • DISC1
  • CENTD3 is an interaction partner for VAV2
  • is a GTPase-activating protein (GAP) that inactivates ARF6 and RHOA small GTPases
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Arap3 deficiency in mice causes a sprouting angiogenic defect resulting in embryonic lethality by E11
  • Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia