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FLASH GENE
Symbol AQP8 contributors: mct/npt - updated : 24-11-2007
HGNC name aquaporin 8
HGNC id 642
Location 16p12      Physical location : 25.228.284 - 25.240.252
Synonym name aquaporin 8, water channel forming integral protein
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     6 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
6 - 1315 27.2 261 - -
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon predominantly
Endocrinepancreas   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • six transmembrane segments (6TM)
  • intracellular N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • MIP/aquaporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • ‘‘orthodox’’aquaporin, that transport only water molecules (Sorani 2008)
  • forming a water-specific channel, mercury-sensitive
  • not permeable to glycerol or urea
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS