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FLASH GENE
Symbol AQP7 contributors: mct/npt - updated : 29-09-2007
HGNC name aquaporin 7
HGNC id 640
Location 9p13.3      Physical location : 33.384.948 - 33.402.517
Synonym name
  • aquaporin adipose
  • aquaporin 7, water channel forming integral protein
  • Synonym symbol(s) AQP9, AQP7L, AQPAP, MGC149555, MGC149556
    DNA
    TYPE functioning gene
    STRUCTURE 17.57 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Binding site   HRE
    text structure insulin response element in the promoter and putative peroxisome proliferator element (PPRE)
    MAPPING cloned Y linked N status provisional
    Physical map
    APTX 9p13.3 aprataxin DNAJA1 9p13-p12 DnaJ (Hsp40) homolog, subfamily A, member 1 SMU-1 9p12 homolog of C. elegans smu-1 B4GALT1 9p13 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 SPINK4 9p12 serine protease inhibitor, Kazal type 4 BAG1 9p12 BCL2-associated athanogene HSPC177 NFX1 9p12 nuclear transcription factor, X-box binding 1 AQP7 9p13 aquaporin 7 AQP3 9p13 aquaporin 3 NOL6 9p13.2 nucleolar protein family 6 (RNA-associated) bA255A11.3 9p12 FLJ35740 pseudogene LOC389711 9 similar to hypothetical protein DKFZp434F1719 TRBV20OR9-2 9p21 T cell receptor beta variable 20/OR9-2 ANXA2P2 9p13 annexin A2 pseudogene 2 TRBV21OR9-2 9p21 T cell receptor beta variable 21/OR9-2 TRBV22OR9-2 9p21 T cell receptor beta variable 22/OR9-2 TRBV23OR9-2 9p21 T cell receptor beta variable 23/OR9-2 TRBV24OR9-2 9p21 T cell receptor beta variable 20/OR9-2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1258 - 342 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousnervecranial nerve  highly
    Reproductivefemale systembreastmammary gland highly
     male systemprostate   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • six transmembrane segments (6TM)
  • intracellular N and C termini
  • HOMOLOGY
    Homologene
    FAMILY
  • MIP family
  • aquaglyceroporin family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water (Sorani 2008)
  • water channel forming integral protein
  • putatively involved in the formation of late spermatids
  • may be responsible for the increase of plasma glycerol during exercise, and for glycerol permeability and other small solutes
  • acting as a glycerol gateway molecule in adipocytes for the efficient release of glycerol and protecting against obesity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    repressed by insulin via insulin response element of the promoter
    Other adipose tissue expression is regulated by fasting-refeeding, insulin, dexamethasone, TNF, isoproterenol, and peroxisome proliferator-activated receptor PPARA, PPARG
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in severely obese women
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target aquaporins appear to be important for the development of novel drug therapies for Meniere's disease and related disorders (Takeda 2009)
    ANIMAL & CELL MODELS
    Aqp7 disruption in mouse associated with obesity