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FLASH GENE
Symbol AQP12A contributors: mct/pgu - updated : 17-01-2009
HGNC name aquaporin 12A
HGNC id 19941
Location 2q37.3      Physical location : 241.631.261 - 241.637.899
Synonym name aquaporin X2
Synonym symbol(s) AQP12, AQPX2
DNA
TYPE functioning gene
STRUCTURE 6.64 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
Map cen - D2S2285 - D2S125 - AQP12A - D2S140 - D2S1499E - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1097 - 295 - 2005 15809071
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepancreas exocrine   specific
cells
SystemCellPubmedSpeciesStageRna symbol
Digestiveacinar
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five transmembrane domains
  • one of the two asparagine-proline-alanine (NPA) motifs, which play a crucial role in selective water conduction, are not completely conserved
  • HOMOLOGY
    interspecies ortholog to murine Aqp12
    homolog to chicken AQP12
    Homologene
    FAMILY
  • MIP/aquaporin (TC 1.A.8) family
  • AQP11/AQP12 subfamily, subcellular AQPs family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    text selective localization of AQP12 in pancreatic acinar cells and possibly in the intracellular organelles
    basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water
  • may play a role in digestive enzyme secretion such as maturation and exocytosis of secretory granules
  • acting as a water channel
  • similarly to AQP11, AQP12A is thought to belong to the third group of AQPs because it also has a divergent N-terminal NPA motif
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS