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FLASH GENE
Symbol AQP11 contributors: mct/npt/pgu - updated : 16-01-2009
HGNC name aquaporin 11
HGNC id 19940
Location 11q14.1      Physical location : 77.300.679 - 77.321.401
Synonym symbol(s) AQPX1, AQP-11
DNA
TYPE functioning gene
STRUCTURE 20.01 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D11S4079 - D11S906 - AQP11 - D11S3459 - D11S4166 - qter
Authors UCSC (2009)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1561 - 271 - Gorelick (2006)
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an Asn-Pro-Cys (NPC) motif, corresponding to the N-terminal Asn-Pro-Ala (NPA) signature motif of conventional AQPs, this NPC motif, unlike the NPA motif of known AQPs, is essential for full functional expression of the molecule
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Aqp11
    Homologene
    FAMILY
  • MIP/aquaporin family
  • AQP11/AQP12 subfamily, subcellular AQPs family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • aquaglyceroporins, that transport glycerol
  • and small solutes in addition to water
  • may be essential for the proximal tubular function
  • may also function as water channel
  • played significant roles in mammalian spermatogenesis and salivary gland development
  • having a potential role in kidney development
  • similarly to AQP11, AQP12A is thought to belong to the third group of AQPs because it also has a divergent N-terminal NPA motif
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Aqp11-null mice die in the neonatal period due to renal failure with progressive renal cyst formation, suggesting the importance of Aqp11 in mammalian kidney development