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FLASH GENE
Symbol APOPT1 contributors: mct - updated : 07-10-2014
HGNC name apoptogenic 1, mitochondrial
HGNC id 20492
Corresponding disease
APOPT1D APOPT1deficiency
Location 14q32.32      Physical location : -
Genatlas name apoptogenic 1
Synonym name
  • chromosome 14 open reading frame 153
    • Synonym symbol(s) MGC2562, C14orf153, Apop-1, APOP
    DNA
    TYPE functioning gene
    STRUCTURE 27.94 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 1244 - 206 - 2006 16782708
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineparathyroid   highly
    Lymphoid/Immunelymph node    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal mitochondrial targeting sequence that is eventually cleaved off from the mature protein
    • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text likely specifically localized in the mitochondrial matrix
    basic FUNCTION
  • plays roles in cell death under physiological conditions
  • elusive mitochondrial protein, which appears to be actively eliminated by proteasome degradation, but be stabilized by, and participate in, a stress-induced program related to ROS production
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • inhibition of APOPT1-induced death by IGF1 is mediated by the activation of the PI3K/Akt signaling pathway
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) APOPT1D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS