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FLASH GENE
Symbol APOOL contributors: mct - updated : 21-11-2017
HGNC name apolipoprotein O-like
HGNC id 24009
Location Xq21.1      Physical location : 84.258.897 - 84.348.324
Synonym name
  • chromosome X open reading frame 33
  • family with sequence similarity 121A
  • protein FAM121A
  • Synonym symbol(s) UNQ8193, CXorf33, MGC129748 , AAIR8193, FAM121A, Mic27
    DNA
    TYPE functioning gene
    STRUCTURE 89.47 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 6479 29 268 - 2015 25764979
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel    
    Digestivemouthtongue   
    Lymphoid/Immunelymph node    
    Urinarybladder    
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo
    Text stem cell
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to murine 9430083G14Rik
    Homologene
    FAMILY
  • apolipoprotein O family
  • FAM121 family
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    basic FUNCTION
  • is a mitochondrial membrane protein facing the intermembrane space
  • is a cardiolipin-binding component of the IMMT/MINOS protein complex determining cristae morphology in mammalian mitochondria
  • APOO and APOOL, regulate their levels in an antagonistic manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CHCHD6, APOOL and APOO appear to be periphery subunits of the MICOS complex, because their depletion does not affect cristae morphology or stability of other components
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • bind the mitochondrial phospholipid cardiolipin (CL) and interact physically with this complex
  • APOOL physically interacts with several subunits of the MINOS complex, namely IMMT, MINOS1, and SAMM50
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    led to fragmentation of mitochondria, a reduced basal oxygen consumption rate, and altered cristae morphology
    constitutional     --low  
    impaired mitochondrial respiration and caused major alterations in cristae morphology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS