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FLASH GENE
Symbol APOL3 contributors: mct - updated : 08-04-2011
HGNC name apolipoprotein L, 3
HGNC id 14868
Location 22q13.1      Physical location : 36.536.371 - 36.562.225
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text APOL1-APOL4 are clustered on human chromosome 22q13.1
STRUCTURE 25.85 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Map cen - APOL6 - APOL5 - APOL3 - APOL2 - APOL1 - qter
Authors Page (01)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3632 42.7 388 - 2001 11374903
4 - 3793 40.1 363 - 2001 11374903
3 - 2123 44.3 402 - 2001 11374903
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Nervousbrain    
Reproductivemale systemprostate  highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text placenta,liver
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conserved amphipathic alpha helices
HOMOLOGY
Homologene
FAMILY APOL family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
basic FUNCTION
  • may be affecting the movement of lipids in the cytoplasm or allow the binding of lipids to
  • organelles.
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to prostate cancer (HPC)
    Variant & Polymorphism SNP rs2097365, rs2017329, rs2097465, having the strongest association with HPC risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS