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FLASH GENE
Symbol APOL2 contributors: mct - updated : 08-04-2011
HGNC name apolipoprotein L, 2
HGNC id 619
Location 22q13.1      Physical location : 36.622.255 - 36.636.000
Synonym symbol(s) APOL-II
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text APOL1-APOL4 are clustered on human chromosome 22q13.1
STRUCTURE 13.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence cytosine-phosphate-guanine/HTF
Binding site   transcription factor
text structure
  • at least a SP1 site,a number of AP1 and AP4 sites,at least a GC box,multiple zinc finger-binding sites and at least a sterol regulatory element-binding protein site and at least 2 conserved initiator sequences
  • two polyadenylation signals within the 3-prime untranslated region
  • MAPPING cloned Y linked N status provisional
    Map see MYH9
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2545 37.1 337 - Duchateau
    encoding the same protein
    - splicing 2686 37.1 337 - Duchateau
  • encoding the same protein
  • differing in the 5' UTR compared to variant alpha
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     intestinelarge intestinecolon  
     liver    
     mouth    
     salivary gland    
    Endocrineadrenal gland    
     pancreas   highly
    Lymphoid/Immunespleen    
     thymus   highly
    Nervousbrain   highly
     spinal cord    
    Reproductivefemale systembreastmammary gland  
     female systemuterus   
     male systemprostate  highly
     male systemtestis   
    Respiratorylung   highly
     respiratory tracttrachea   
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Lymphoid    
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion only found in lymph
    at STAGE
    physiological period fetal, pregnancy
    Text placenta highly,fetal brain and liver
    PROTEIN
    PHYSICAL PROPERTIES Amphiphilic
    STRUCTURE
    motifs/domains
    secondary structure predicted amphipathic alpha helix
    conjugated LipoP
    HOMOLOGY
    intraspecies paralog to APOL1
    Homologene
    FAMILY apolipoprotein L gene family
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • affecting the movement of lipids
  • allowing the binding of lipids to organelles.
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text lipid transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by tumor necrosis factor-alpha (TNFA)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS