basic FUNCTION
| may be RNA editing enzymes and have roles in growth or cell cycle control |
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having a function to neutralize specific lentiviruses |
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may potentially contribute to the cytosine mutation clusters observed in many cancers |
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appears to restrict engineered L1 retrotransposition in a broad range of cell types, including pluripotent cells  |
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APOBEC3B and AICDA have similar nuclear import mechanisms  |
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aberrant expression of APOBEC3B can evoke genomic instability by inducing base substitutions into human genome, which might lead to tumorigenesis in human cells  |
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role in innate immune responses, and source of mutation in cervical, bladder, lung, head and neck, and breast cancers  |
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APOBEC3A- and APOBEC3B-induced mutagenesis primarily results from the deamination of the lagging strand template during DNA replication  |
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APOBEC3 proteins function within the innate immune system by mutating DNA of viral genomes and retroelements to restrict infection and retrotransposition  |