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FLASH GENE
Symbol APOBEC2 contributors: mct/npt/pgu - updated : 23-06-2010
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
HGNC id 605
Location 6p21.1      Physical location : 41.020.939 - 41.032.629
Synonym name probable C->U-editing enzyme APOBEC-2
Synonym symbol(s) ARCD1, ARP1, APOBEC-2
EC.number 3.5.4.-
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
STRUCTURE 11.69 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site
text structure functional NF-kappaB response elements in the 5' untranslated region of the gene
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1643 25.7 224 - 2007 17187054
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinepancreas    
Nervousnerve    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cytidine deaminase motif
  • a C terminal leucine rich region
  • secondary structure two long alpha-helices of a monomer structure prevent the formation of a square-shaped tetramer and facilitate formation of the rod-shaped tetramer via head-to-head interactions of two APO2 dimers
    mono polymer tetramer
    HOMOLOGY
    intraspecies homolog to APOBEC1
    Homologene
    FAMILY
  • apolipoprotein B messenger RNA-editing enzyme catalytic (APOBEC) polypeptides family
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • RNA-specific cytidine deaminase (probable C to U editing enzyme)
  • having a low intrinsic cytidine deaminase activity
  • cytidine deaminase interacting with APOBEC1 and A1CF to inhibit apoB mRNA editing, possibly through interaction with other protein components of the apoB RNA editing holoenzyme
  • playing a possible role in the pathophysiology of hepatic inflammation
  • essential for normal muscle development and maintenance of fiber-type ratios, but its molecular function remains to be identified, biochemical analyses doing not especially argue for any role in RNA editing
  • may deaminate a substrate other than a polynucleotide, or the possibility even remains that it might fulfill some structural role without displaying any deaminase activity at all (Sato 2010)
  • selective inhibitor of TGFB signaling, regulating left-right axis specification during early embryogenesis
  • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • catalytic polypeptide 2 component of mRNA editing enzyme
  • forms a rod-shaped tetramer that differs markedly from the square-shaped tetramer of the free nucleotide cytidine deaminase, with which APOBEC proteins share considerable sequence homology
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • zn2+
  • protein
  • interacts and heterodimerizes with both APOBEC1 and APOBEC1 complementation factor (A1CF)
  • cell & other
    REGULATION
    induced by by TGFB signaling
    Other transcriptionally regulated by NF-kappaB in hepatocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Apobec2-deficient mice harbor a markedly increased ratio of slow to fast fibers in soleus muscle and exhibit an &
    8764;1520p100 reduction in body mass from birth onwards, with elderly mutant animals revealing clear histological evidence of a mild myopathy