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FLASH GENE
Symbol APOBEC1 contributors: mct/npt - updated : 28-03-2018
HGNC name apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
HGNC id 604
Location 12p13.31      Physical location : 7.801.996 - 7.818.502
Synonym name
  • apolipoprotein B mRNA editing enzyme complex-1
  • apolipoprotein B mRNA editing enzyme
  • Synonym symbol(s) APOBMEP, BEDP, CDAR1, apobec-1, HEPR
    EC.number 3.5.4.-
    DNA
    TYPE functioning gene
    STRUCTURE 16.51 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    GRCC9 12p13.31 likely ortholog of mouse gene rich cluster, C9 gene B7 12p13 B7 gene ENO2 12p13.31 enolase 2, (gamma, neuronal) DRPLA 12p13.31 dentatorubral-pallidoluysian atrophy (atrophin-1) GRCC10 12p13.31 likely ortholog of mouse gene rich cluster, C10 gene PTPN6 12p13.31 protein tyrosine phosphatase, non-receptor type 6 REA 12p13.31 protein tyrosine phosphatase, non-receptor type 6 C2F 12p13 C2f protein LOC390285 12 similar to vav-1 interacting Kruppel-like protein isoform b C1S 12p13.31 complement component 1, s subcomponent C1R 12p13.31 complement component 1, r subcomponent C1RL 12p13.31 complement component 1, r subcomponent-like LOC283314 12p13.31 hypothetical protein LOC283314 RBP5 12p13.2 retinol binding protein 5, cellular CLSTN3 12p13.31 calsyntenin 3 PXR1 12p13.31 peroxisome receptor 1 LOC341392 12p13.31 similar to olfactory specific medium-chain acyl CoA synthetase M160 12p13.31 scavenger receptor cysteine-rich type 1 protein M160 CD163 12p13.3 CD163 antigen LOC390286 12 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) APOBEC1 12p13.2-p13.1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 GDF3 12p13.1 growth differentiation factor 3 LOC338759 12p13.31 STELLA CLECSF11 12p13.2-p12.3 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11 LOC360030 12p13.31 homeobox C14 NANOG 12p13.31 Nanog homeobox SLC2A14 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 14 SLC2A3 12p13.3 solute carrier family 2 (facilitated glucose transporter), member 3 LOC283320 12p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) FHX 12pter-p13.31 similar to 60 kDa heat shock protein, mitochondrial precursor (Hsp60) (60 kDa chaperonin) (CPN60) (Heat shock protein 60) (HSP-60) (Mitochondrial matrix protein P1) (P60 lymphocyte protein) (HuCHA60) C3AR1 12p13.3-p13.1 complement component 3a receptor 1 DKFZP566B183 12p13.31 DKFZP566B183 protein CLECSF6 12p13.1 C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 LOC283321 12p13.31 hypothetical LOC283321 LOC387828 12 LOC387828 FLJ10408 12p13.31 hypothetical protein FLJ10408 LOC387829 12 similar to Asparagine-linked glycosylation 1 homolog (yeast, beta-1,4-mannosyltransferase) LOC387830 12 similar to CG7889-PA LOC93320 12p13.31 similar to Alkaline sphingomyelinase
    RNA
    TRANSCRIPTS type messenger
    text alternative splicing
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 911 28 236 - Hadjiagapiou, Bennett (2006)
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a mooring sequence to promote editing of an appropriably located cytidine
  • a C terminal leucine rich region
  • alpha helix
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Apobec1
    homolog to E.coli Cda
    intraspecies homolog to APOBEC2
    Homologene
    FAMILY
  • RNA-editing deaminase family
  • cytidine and deoxycytidylate deaminase family
  • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text nucleo-cytoplasmic trafficking protein
    basic FUNCTION
  • responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA
  • editing HBV DNA (Gonzalez 2009)
  • act through an RNA-interacting cofactor, APOBEC1 complementation factor (ACF) (Nonaka 2009)
  • CELLULAR PROCESS protein, editing
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
  • part of the apolipoprotein B mRNA editing complex
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • Zn2+
  • protein
  • interacting with A1CF)
  • BAG4 binds to APOBEC1 via its N-terminal region independent of the BAG domain
  • SYNCRIP is involved in viral replication, neural morphogenesis, modulation of circadian oscillation, and the regulation of the cytidine deaminase APOBEC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    phosphorylation of ACF (APOBEC-1 complementation factor) by PKC may be a key regulatory mechanism of APOBEC1 in rat hepatocytes (Lehmann 2007)